Outer membrane alterations in multiresistant mutants of Pseudomonas aeruginosa selected by ciprofloxacin.

作者信息

Legakis N J, Tzouvelekis L S, Makris A, Kotsifaki H

机构信息

Department of Microbiology, School of Health Sciences, Goudi, Athens, Greece.

出版信息

Antimicrob Agents Chemother. 1989 Jan;33(1):124-7. doi: 10.1128/AAC.33.1.124.

Spontaneous mutants of Pseudomonas aeruginosa selected by ciprofloxacin were studied for outer membrane alterations. Acquisition of ciprofloxacin resistance was at least partially related to defects in lipopolysaccharide synthesis. When ciprofloxacin resistance was combined with resistance to beta-lactams and aminoglycosides, several alterations in outer membrane proteins were noted.