管花苷-1 通过诱导 MET 的泛素化抑制胶质母细胞瘤的生长、迁移和侵袭。
Tubeimoside-1 Inhibits Glioblastoma Growth, Migration, and Invasion via Inducing Ubiquitylation of MET.
机构信息
Chongqing Engineering Research Center of Antitumor Natural Drugs, Chongqing Three Gorges Medical College, Chongqing 404120, China.
State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400715, China.
出版信息
Cells. 2019 Jul 25;8(8):774. doi: 10.3390/cells8080774.
Tubeimoside-1 (TBMS1) is one of the extracts of rhizoma bolbostemmae, which has remarkable anti-cancer function in the treatment of esophagus and gastric cancer in traditional Chinese medicine. However the mechanisms of its anti-cancer function is remain unclear. In this study, we demonstrate that TBMS1 could inhibit cell growth and metastasis in glioblastoma. MET is a member of the receptor tyrosine kinase family, which amplifies frequently in various human cancers. As an important proto-oncogene, multiple inhibitors have been developed for the therapy of cancers. Here, we found TBMS1 could reduce/decrease the protein level of MET via increasing its Ubiquitination degradation. Therefore, TBMS1 is a promising compound for the treatment of glioblastoma and an inhibitor of MET.
冬凌草甲素（TBMS1）是冬凌草的提取物之一，在中医治疗食管癌和胃癌方面具有显著的抗癌功能。然而，其抗癌功能的机制尚不清楚。在这项研究中，我们证明 TBMS1 可以抑制神经胶质瘤中的细胞生长和转移。MET 是受体酪氨酸激酶家族的成员，在各种人类癌症中经常扩增。作为一个重要的原癌基因，已经开发出多种抑制剂用于癌症的治疗。在这里，我们发现 TBMS1 可以通过增加其泛素化降解来降低/减少 MET 的蛋白水平。因此，TBMS1 是治疗神经胶质瘤和 MET 抑制剂的一种有前途的化合物。
Zotero 插件