a Comprehensive Liver Cancer Center, 5th Medical Center of Chinese PLA General Hospital , Beijing , PR China.
b Radiology Department, 5th Medical Center of Chinese PLA General Hospital , Beijing , PR China.
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3067-3071. doi: 10.1080/21691401.2019.1640228.
Long non coding RNAs (lncRNAs) are important in the occurrence and development of various cancers. They have been considered to participate in many processes of diseases. In this study, we aimed at investigating expression level and clinical significance of lncRNA X91348 in hepatocellular carcinoma (HCC). The expression of X91348 in tissue and serum samples from patients with HCC and from healthy people was detected through quantitative real-time polymerase chain reaction (qRT-PCR). X91348 expression was decreased in patients with HCC compared with healthy controls no matter in tissue or serum samples. The relationship between X91348 expression and clinicopathologic characteristics was analysed. The result demonstrated that tumour size, HBsAg and Child-Pugh were vital influencing factors for X91348 expression, which revealed X91348 may be involved in the progress of HCC. Kaplan-Meier analysis was used to evaluate overall survival of patients with different expressions of X91348. Finally, prognostic value of X91348 in HCC was assessed cox regression analysis. X91348 was proved to be closely related to the prognosis of HCC. Taken together, the down-regulation of X91348 could be an independent diagnostic and prognostic indicator for HCC.
长链非编码 RNA（lncRNAs）在各种癌症的发生和发展中起着重要作用。它们被认为参与了疾病的许多过程。在这项研究中，我们旨在研究 lncRNA X91348 在肝细胞癌（HCC）中的表达水平和临床意义。通过定量实时聚合酶链反应（qRT-PCR）检测 HCC 患者和健康人组织和血清样本中的 X91348 表达。无论在组织还是血清样本中，与健康对照组相比，HCC 患者的 X91348 表达均降低。分析了 X91348 表达与临床病理特征的关系。结果表明，肿瘤大小、HBsAg 和 Child-Pugh 是 X91348 表达的重要影响因素，表明 X91348 可能参与了 HCC 的进展。Kaplan-Meier 分析用于评估不同 X91348 表达患者的总生存率。最后，通过 Cox 回归分析评估 X91348 在 HCC 中的预后价值。X91348 与 HCC 的预后密切相关。综上所述，X91348 的下调可能是 HCC 的一个独立诊断和预后指标。
