Suffolk Raymond, Agertoft Lone, Johansen Malene, Zachariassen Gitte
Paediatric Department, Hospital of Southern Jutland, Aabenraa, Denmark.
Paediatric, H.C. Andersens Children Hospital, Odense, Denmark.
BMJ Case Rep. 2019 Jul 26;12(7):e229255. doi: 10.1136/bcr-2019-229255.
This case report is about a boy born extremely preterm at gestational age of 24 weeks, with extremely low birth weight, developing severe bronchopulmonary dysplasia and in need of mechanical ventilation for 155 days. He also had five recurrent infections with group B streptococcus (GBS) within 4 months from birth, and his respiratory condition clearly deteriorated with every GBS infection. It was difficult to wean him from mechanical ventilation. Finally he was extubated when he was 7 months old and kept out of mechanical ventilation after receiving high-dose methylprednisolone, given according to international recommendations. After GBS was cultured for the fifth time, he received oral rifampicin along with intravenous penicillin and after this treatment, GBS did not occur again. At the age of 22 months, the boy no longer needed any respiratory support and he was about 6 months late in his neurological development.
本病例报告讲述的是一名孕24周极早产男婴，出生体重极低，患有严重支气管肺发育不良，需要机械通气155天。他在出生后4个月内还5次复发B族链球菌（GBS）感染，每次GBS感染后其呼吸状况明显恶化。很难让他脱离机械通气。最后，他在7个月大时拔管，并按照国际建议接受大剂量甲基强的松龙治疗后不再需要机械通气。在第5次培养出GBS后，他接受了口服利福平以及静脉注射青霉素治疗，此后GBS未再出现。在22个月大时，该男婴不再需要任何呼吸支持，其神经发育延迟约6个月。
