Arizona State University, Tempe, AZ, 85287, USA.
Sci Rep. 2019 Jul 26;9(1):10881. doi: 10.1038/s41598-019-47366-3.
Blood based biomaterials are widely researched and used in different biomedical applications including cell therapy, drug delivery, sealants etc. due to their biocompatibility and biodegradability. Blood derived gels are successfully used in clinical studies due to the presence of fibrinogen and several platelet growth factors. In spite of their wide applications, it is challenging to use blood-based biomaterials due to their low mechanical stability, poor adhesive property and contamination risk. In this study, we used porcine plasma to form gel in presence of biodegradable synthetic crosslinkers. Mechanical strength of this plasma gel could be tailored by altering the amount of crosslinkers for any desired biomedical applications. These plasma gels, formed by the synthetic crosslinkers, were utilized as a drug delivery platform for wound healing due to their low cytotoxicity. A model drug release study with these plasma gels indicated slow and sustained release of the drugs.
基于血液的生物材料由于其生物相容性和可生物降解性，被广泛应用于细胞治疗、药物输送、密封剂等不同的生物医学领域。由于纤维蛋白原和多种血小板生长因子的存在，血液衍生凝胶在临床研究中得到了成功应用。尽管它们的应用广泛，但由于其机械稳定性低、粘附性能差和污染风险，使用基于血液的生物材料具有挑战性。在这项研究中，我们使用猪血浆在可生物降解的合成交联剂的存在下形成凝胶。通过改变交联剂的用量，可以调整这种血浆凝胶的机械强度，以满足任何所需的生物医学应用。由于这些合成交联剂形成的血浆凝胶具有低细胞毒性，因此可用作伤口愈合的药物输送平台。通过这些血浆凝胶进行的模型药物释放研究表明，药物可以缓慢且持续释放。
