Junge J, Bentsen K D, Christoffersen P, Orholm M, Sørensen T I, Horn T
Department of Pathology, Hvidovre Hospital, University of Copenhagen, Denmark.
Br Med J (Clin Res Ed). 1988 Jun 11;296(6637):1629-30. doi: 10.1136/bmj.296.6637.1629.
In a study of 142 male alcohol abusers without evidence of cirrhosis the presence of intralobular fibronectin in the liver was investigated in relation to the subsequent development of the disease. All 142 initial biopsy samples showed preserved architecture. During a follow up period of 10-13 years 23 patients (16%) developed cirrhosis. Twelve of 110 patients with normal or slightly increased amounts of parenchymal fibronectin in the initial biopsy specimen developed cirrhosis, whereas eight out of 27 patients with moderately increased amounts and three out of five with significantly increased amounts later developed the disease (p less than 0.005). Semiquantitative assessment of the amount of parenchymal fibronectin at an early stage of alcoholic liver disease is of definite predictive value for the development of cirrhosis.
在一项针对142名无肝硬化证据的男性酗酒者的研究中，对肝脏小叶内纤维连接蛋白的存在情况与该疾病随后的发展进行了调查。所有142份初始活检样本均显示结构保存完好。在10至13年的随访期内，23名患者（16%）发展为肝硬化。在初始活检标本中实质纤维连接蛋白含量正常或略有增加的110名患者中有12名发展为肝硬化，而在实质纤维连接蛋白含量中度增加的27名患者中有8名以及在含量显著增加的5名患者中有3名后来发展为该疾病（p<0.005）。在酒精性肝病早期对实质纤维连接蛋白含量进行半定量评估对肝硬化的发展具有明确的预测价值。
