• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

外用抗皱面霜治疗外眦纹的比较

Comparison of topical antiaging creams in the management of lateral canthal lines.

作者信息

Carroll Julia M, Hanna Sam, Guenther Lyn C, Boucher Nathalie

机构信息

Compass Dermatology, Toronto, ON, Canada.

Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada.

出版信息

J Cosmet Dermatol. 2020 Mar;19(3):694-704. doi: 10.1111/jocd.13062. Epub 2019 Jul 26.

DOI:10.1111/jocd.13062
PMID:31350814
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7027448/
Abstract

OBJECTIVE

This study compared an antiaging treatment with two currently marketed cosmetic antiaging products for the treatment of lateral canthal lines ("crow's feet").

METHODS

Healthy female volunteers (72) aged of 54.6 years (mean) having fine-to-moderate wrinkles in the lateral canthal areas were randomized to one of three treatments applied daily over 28 days: Group A (Purgenesis™ Day Cream, Purgenesis™ Eye Cream, and Purgenesis™ Night Cream); Group B (Prevage Eye Lotion, Prevage Day Cream, and Prevage Night Cream); or Group C (La Mer Eye Balm, Crème de La Mer , and La Mer Night Cream). The effects on anti-wrinkle properties and for sensory attributes and general performance were evaluated on Days 1, 7, and 28.

RESULTS

Skin hydration improved significantly at all time points in Groups A and B, and at Day 28 in Group C. Group A patients experienced significant improvements in measured skin elasticity parameters at Day 28; extensibility and maximum amplitude were significantly better at Day 28 in Groups B and C. Benefits were also seen in profilometric parameters with statistical significance only in Group A Volunteer tolerance was good with all three treatments, although moderate and high levels of adverse events were numerically higher in Group B than in Groups A or C, and levels of slight discomfort were significantly more prevalent in Group B.

CONCLUSION

The Purgenesis™ antiaging treatment significantly improved skin hydration, elasticity, and profilometry parameters during a 28-day study. This therapy was found to be well tolerated and effective in countering the cutaneous signs of aging.

摘要

目的

本研究将一种抗老化治疗方法与两种目前市场上销售的美容抗老化产品进行比较，以治疗外眦纹（“鱼尾纹”）。

方法

72名平均年龄为54.6岁、外眦区域有轻度至中度皱纹的健康女性志愿者被随机分为三组，在28天内每天接受一种治疗：A组（Purgenesis™日霜、Purgenesis™眼霜和Purgenesis™晚霜）；B组（Prevage眼部护理液、Prevage日霜和Prevage晚霜）；或C组（海蓝之谜眼霜、海蓝之谜精华面霜和海蓝之谜晚霜）。在第1天、第7天和第28天评估对抗皱性能、感官属性和总体表现的影响。

结果

A组和B组在所有时间点皮肤水合作用均显著改善，C组在第28天皮肤水合作用显著改善。A组患者在第28天测量的皮肤弹性参数有显著改善；B组和C组在第28天的伸展性和最大幅度显著更好。在轮廓测量参数方面也有改善，但仅在A组有统计学意义。所有三种治疗方法志愿者耐受性良好，尽管B组中度和高度不良事件在数量上高于A组或C组，且B组轻度不适水平显著更普遍。

结论

在为期28天的研究中，Purgenesis™抗老化治疗显著改善了皮肤水合作用、弹性和轮廓测量参数。发现该疗法耐受性良好，对对抗皮肤衰老迹象有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/34ad032d8c87/JOCD-19-694-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/e17c2af9504d/JOCD-19-694-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/898ac21ca08e/JOCD-19-694-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/5c9a806d9158/JOCD-19-694-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/0e988fb0adc9/JOCD-19-694-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/1a9515b489e8/JOCD-19-694-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/7a386c017d1c/JOCD-19-694-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/e04031d8214d/JOCD-19-694-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/af52c2b93208/JOCD-19-694-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/b1a5571dec99/JOCD-19-694-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/9d3d4ae36377/JOCD-19-694-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/f4b2ce174ca1/JOCD-19-694-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/0a3ed66c49a9/JOCD-19-694-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/95c95283337a/JOCD-19-694-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/34ad032d8c87/JOCD-19-694-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/e17c2af9504d/JOCD-19-694-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/898ac21ca08e/JOCD-19-694-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/5c9a806d9158/JOCD-19-694-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/0e988fb0adc9/JOCD-19-694-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/1a9515b489e8/JOCD-19-694-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/7a386c017d1c/JOCD-19-694-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/e04031d8214d/JOCD-19-694-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/af52c2b93208/JOCD-19-694-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/b1a5571dec99/JOCD-19-694-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/9d3d4ae36377/JOCD-19-694-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/f4b2ce174ca1/JOCD-19-694-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/0a3ed66c49a9/JOCD-19-694-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/95c95283337a/JOCD-19-694-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61bc/7027448/34ad032d8c87/JOCD-19-694-g014.jpg

相似文献

1
Comparison of topical antiaging creams in the management of lateral canthal lines.外用抗皱面霜治疗外眦纹的比较
J Cosmet Dermatol. 2020 Mar;19(3):694-704. doi: 10.1111/jocd.13062. Epub 2019 Jul 26.
2
Antiaging efficacy of a retinaldehyde-based cream compared with glycolic acid peel sessions: A randomized controlled study.基于视黄醛的面霜与乙醇酸焕肤治疗相比的抗衰功效：一项随机对照研究。
J Cosmet Dermatol. 2018 Dec;17(6):1136-1143. doi: 10.1111/jocd.12511. Epub 2018 Jul 19.
3
Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration.负载腺苷的可溶解微针贴片可改善皮肤皱纹、真皮密度、弹性和水合作用。
Int J Cosmet Sci. 2018 Apr;40(2):199-206. doi: 10.1111/ics.12453.
4
A novel, volumizing cosmetic formulation significantly improves the appearance of target Glabellar lines, nasolabial folds, and crow's feet in a double-blind, vehicle-controlled clinical trial.在一项双盲、赋形剂对照的临床试验中，一种新型的、具有丰盈效果的化妆品配方显著改善了眉间纹、鼻唇沟和鱼尾纹的外观。
J Drugs Dermatol. 2014 Jan;13(1):41-6.
5
A Double-Blind, 12-Week Study to Evaluate the Antiaging Efficacy of a Cream Containing the NFκB Inhibitor 4-Hexyl-1, 3-Phenylenediol and Ascorbic Acid-2 Glucoside in Adult Females.一项双盲、为期12周的研究，旨在评估含有NFκB抑制剂4-己基-1,3-苯二酚和抗坏血酸-2-葡糖苷的面霜对成年女性的抗衰功效。
J Drugs Dermatol. 2016 Jun 1;15(6):750-8.
6
Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream.新型多组分抗衰老眼部外用乳膏的疗效和安全性综合评价。
Skin Res Technol. 2024 Jul;30(7):e13790. doi: 10.1111/srt.13790.
7
Combinatorial application of dissolving microneedle patch and cream for improvement of skin wrinkles, dermal density, elasticity, and hydration.溶解微针贴剂与乳膏的联合应用改善皮肤皱纹、真皮密度、弹性和保湿性。
J Cosmet Dermatol. 2019 Aug;18(4):1083-1091. doi: 10.1111/jocd.12807. Epub 2018 Oct 29.
8
Confirmed efficacy of topical nifedipine in the treatment of facial wrinkles.证实了局部硝苯地平治疗面部皱纹的疗效。
J Dermatolog Treat. 2014 Aug;25(4):319-25. doi: 10.3109/09546634.2013.802759. Epub 2013 Jun 2.
9
Novel topical dermal repair: A clinical analysis.新型局部皮肤修复：临床分析。
J Cosmet Dermatol. 2019 Aug;18(4):1025-1029. doi: 10.1111/jocd.12990. Epub 2019 May 23.
10
[Anti-wrinkle creams with hyaluronic acid: how effective are they?].含透明质酸的抗皱面霜：它们的效果如何？
MMW Fortschr Med. 2016 May 25;158 Suppl 4:1-6. doi: 10.1007/s15006-016-8302-1.

引用本文的文献

1
Skin Ageing: A Progressive, Multi-Factorial Condition Demanding an Integrated, Multilayer-Targeted Remedy.皮肤衰老：一种渐进性、多因素病症，需要综合、多层靶向治疗方案。
Clin Cosmet Investig Dermatol. 2023 May 9;16:1215-1229. doi: 10.2147/CCID.S408765. eCollection 2023.

本文引用的文献

1
Study of antioxidant properties of thylakoids and application in UV protection and repair of UV-induced damage.研究类囊体的抗氧化特性及其在 UV 防护和修复 UV 诱导损伤中的应用。
J Cosmet Dermatol. 2019 Dec;18(6):1980-1991. doi: 10.1111/jocd.12936. Epub 2019 Apr 1.
2
[Skin ageing-General features of facial ageing and therapeutic choices].[皮肤老化——面部老化的一般特征及治疗选择]
Ann Dermatol Venereol. 2019 Jan;146(1):41-74. doi: 10.1016/j.annder.2018.10.015. Epub 2018 Dec 20.
3
Natural Antioxidants: Multiple Mechanisms to Protect Skin From Solar Radiation.
天然抗氧化剂：保护皮肤免受太阳辐射的多种机制。
Front Pharmacol. 2018 Apr 24;9:392. doi: 10.3389/fphar.2018.00392. eCollection 2018.
4
The skin aging exposome.皮肤衰老暴露组
J Dermatol Sci. 2017 Mar;85(3):152-161. doi: 10.1016/j.jdermsci.2016.09.015. Epub 2016 Sep 28.
5
Polyphenols as active ingredients for cosmetic products.多酚类作为化妆品的活性成分。
Int J Cosmet Sci. 2015 Oct;37(5):455-64. doi: 10.1111/ics.12218. Epub 2015 Mar 16.
6
Skin Hydration Assessment through Modern Non-Invasive Bioengineering Technologies.通过现代非侵入性生物工程技术进行皮肤水合作用评估。
Maedica (Bucur). 2014 Mar;9(1):33-8.
7
Epilobium angustifolium extract demonstrates multiple effects on dermal fibroblasts in vitro and skin photo-protection in vivo.柳叶菜提取物在体外对真皮成纤维细胞具有多种作用，并在体内具有皮肤光保护作用。
Gen Physiol Biophys. 2013 Sep;32(3):347-59. doi: 10.4149/gpb_2013031. Epub 2013 Jul 2.
8
In vitro antioxidant and in vivo photoprotective effect of pistachio (Pistacia vera L., variety Bronte) seed and skin extracts.开心果（Pistacia vera L.，Bronte 品种）种皮提取物的体外抗氧化和体内光保护作用。
Fitoterapia. 2013 Mar;85:41-8. doi: 10.1016/j.fitote.2012.12.032. Epub 2013 Jan 9.
9
The preliminary study of the relationship between facial movements and wrinkle formation.面部运动与皱纹形成关系的初步研究。
Skin Res Technol. 2012 May;18(2):219-24. doi: 10.1111/j.1600-0846.2011.00557.x. Epub 2011 Aug 25.
10
Evaluation and comparison of composite and split-thickness skin grafts using cutometer mpa 580.使用Cutometer MPA 580对复合皮和中厚皮片进行评估与比较。
Ann Burns Fire Disasters. 2010 Dec 31;23(4):208-13.