Department of Anatomical Science, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
J Tissue Eng Regen Med. 2019 Nov;13(11):2077-2100. doi: 10.1002/term.2945. Epub 2019 Aug 20.
Peripheral nerve damage is a common clinical complication of traumatic injury occurring after accident, tumorous outgrowth, or surgical side effects. Although the new methods and biomaterials have been improved recently, regeneration of peripheral nerve gaps is still a challenge. These injuries affect the quality of life of the patients negatively. In the recent years, many efforts have been made to develop innovative nerve tissue engineering approaches aiming to improve peripheral nerve treatment following nerve injuries. Herein, we will not only outline what we know about the peripheral nerve regeneration but also offer our insight regarding the types of nerve conduits, their fabrication process, and factors associated with conduits as well as types of animal and nerve models for evaluating conduit function. Finally, nerve regeneration in a rat sciatic nerve injury model by nerve conduits has been considered, and the main aspects that may affect the preclinical outcome have been discussed.
周围神经损伤是创伤后发生的一种常见临床并发症，其原因包括事故、肿瘤生长或手术副作用。尽管最近已经改进了新方法和生物材料，但周围神经间隙的再生仍然是一个挑战。这些损伤会对患者的生活质量产生负面影响。近年来，人们已经做出了许多努力，开发创新的神经组织工程方法，旨在改善神经损伤后的周围神经治疗。在这里，我们不仅概述了我们对周围神经再生的了解，还介绍了神经导管的类型、它们的制造工艺以及与导管相关的因素，以及用于评估导管功能的动物和神经模型的类型。最后，考虑了通过神经导管在大鼠坐骨神经损伤模型中的神经再生，并讨论了可能影响临床前结果的主要方面。
