School of Medicine, University of Auckland, Auckland, New Zealand.
School of Medicine, University of Auckland, Auckland, New Zealand.
Nutr Metab Cardiovasc Dis. 2019 Sep;29(9):956-964. doi: 10.1016/j.numecd.2019.06.003. Epub 2019 Jun 14.
The relationship between intra-pancreatic fat deposition (IPFD) and lipid profile has been investigated in individuals with obesity and/or type 2 diabetes, but not in healthy non-obese individuals and those after acute pancreatitis. The aim of the study was to investigate the association between serum lipid profile and IPFD in the latter individuals and to determine the effect of abdominal fat distribution and other covariates.
A total of 90 individuals with a history of acute pancreatitis as well as 23 healthy non-obese individuals participated in the study. Magnetic resonance imaging was used to quantify IPFD and visceral-to-subcutaneous fat volume ratio, followed by fasting state measurement of high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), TC/HDL-C ratio, and triglycerides. In healthy non-obese individuals, IPFD was not significantly associated with any of the studied markers. In individuals after acute pancreatitis, IPFD was significantly associated with triglycerides in both unadjusted (β = 0.360; 95% CI, 0.090-0.629; p = 0.009) and adjusted models, with a β-coefficient of 0.280 [(95% CI, 0.016-0.545); p = 0.038] in the most adjusted model. Also, IPFD was significantly associated with TC/HDL-C ratio in both unadjusted (β = 0.336; 95% CI, 0.045-0.626; p = 0.024) and adjusted models, with a β-coefficient of 0.375 [(95% CI, 0.090-0.660); p = 0.010] in the most adjusted model. Multiple regression yielded triglycerides, but not TC/HDL-C ratio, as a significant marker of IPFD in individuals after acute pancreatitis.
Serum lipid profile is not associated with IPFD in healthy non-obese. Triglycerides, but not other components of lipid profile, is a promising biomarker for IPFD in individuals following acute pancreatitis.
在肥胖和/或 2 型糖尿病患者中，已经研究了胰内脂肪沉积（IPFD）与血脂谱之间的关系，但在健康非肥胖个体和急性胰腺炎后个体中尚未进行研究。本研究旨在调查后者个体中血清脂质谱与 IPFD 之间的关联，并确定腹部脂肪分布和其他协变量的影响。
共有 90 名急性胰腺炎病史的个体和 23 名健康非肥胖个体参加了研究。使用磁共振成像来定量胰内脂肪沉积和内脏到皮下脂肪体积比，然后在空腹状态下测量高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、总胆固醇（TC）、TC/HDL-C 比值和甘油三酯。在健康非肥胖个体中，IPFD 与研究的标志物均无显著相关性。在急性胰腺炎后个体中，IPFD 与甘油三酯在未调整模型（β=0.360；95%置信区间，0.090-0.629；p=0.009）和调整模型中均有显著相关性，在最调整模型中，β 系数为 0.280[（95%置信区间，0.016-0.545）；p=0.038]。此外，IPFD 与 TC/HDL-C 比值在未调整模型（β=0.336；95%置信区间，0.045-0.626；p=0.024）和调整模型中均有显著相关性，在最调整模型中，β 系数为 0.375[（95%置信区间，0.090-0.660）；p=0.010]。多元回归显示，甘油三酯而不是 TC/HDL-C 比值是急性胰腺炎后个体 IPFD 的显著标志物。
血清脂质谱与健康非肥胖个体的 IPFD 无关。甘油三酯，而不是血脂谱的其他成分，是急性胰腺炎后个体 IPFD 的有前途的生物标志物。
