From the Department of Surgery, University of Auckland, Auckland, New Zealand.
Pancreas. 2020 Aug;49(7):924-934. doi: 10.1097/MPA.0000000000001600.
Tobacco smoking and alcohol consumption are established risk factors for pancreatitis. This study investigated the associations between tobacco smoking/alcohol consumption in people after an attack of pancreatitis and intrapancreatic fat deposition (IPFD), intrahepatic fat deposition (IHFD), and skeletal muscle (SMFD) fat deposition.
In this cross-sectional study, magnetic resonance imaging was used to quantify IPFD, IHFD, and SMFD by 2 independent raters. A validated questionnaire was used to determine tobacco smoking and alcohol consumption.
A total of 119 individuals after an attack of pancreatitis were included. Average tobacco smoking contributed most to variance in IPFD (R = 6.5%) and least to variance in SMFD (R = 0.4%). Average alcohol consumption contributed most to variance in variance in IPFD (R = 2.8%) and least to IHFD (R = 1.1%). Packs/day contributed more than years of smoking to variance in IPFD (R = 4.9 and 0.2%, correspondingly), whereas years of drinking contributed more than average daily alcohol consumption (R = 3.9 and 3.2%, correspondingly).
Tobacco smoking and alcohol consumption contributed more to variance in IPFD than IHFD and SMFD. Smoking contributed more than drinking to variance in IPFD. The daily amount of tobacco smoked appeared to be more important than years of smoking for IPFD.
吸烟和饮酒是胰腺炎的既定危险因素。本研究调查了胰腺炎发作后人群中吸烟/饮酒与胰内脂肪沉积（IPFD）、肝内脂肪沉积（IHFD）和骨骼肌（SMFD）脂肪沉积之间的关系。
在这项横断面研究中，使用磁共振成像由 2 名独立评估者定量 IPFD、IHFD 和 SMFD。使用经过验证的问卷确定吸烟和饮酒情况。
共纳入 119 名胰腺炎发作后的个体。平均吸烟对 IPFD 的变异贡献最大（R = 6.5%），对 SMFD 的变异贡献最小（R = 0.4%）。平均饮酒对 IPFD 变异的贡献最大（R = 2.8%），对 IHFD 的贡献最小（R = 1.1%）。包/天对 IPFD 的变异贡献大于吸烟年数（R = 4.9%和 0.2%），而饮酒年数对 IHFD 的贡献大于平均每日饮酒量（R = 3.9%和 3.2%）。
吸烟和饮酒对 IPFD 的变异比 IHFD 和 SMFD 的变异贡献更大。吸烟对 IPFD 的变异贡献大于饮酒。与吸烟年限相比，每天吸烟量似乎对 IPFD 更为重要。
