新诊断2型糖尿病患者胰腺内脂肪沉积与高密度脂蛋白胆固醇降低之间的关联
Association between Intrapancreatic Fat Deposition and Lower High-Density Lipoprotein Cholesterol in Individuals with Newly Diagnosed T2DM.
作者信息
Wang Jianliang, Cai Qingyun, Wu Xiaojuan, Wang Jiaxuan, Chang Xiaona, Ding Xiaoyu, Liu Jia, Wang Guang
机构信息
General Surgery Department, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
出版信息
Int J Endocrinol. 2023 Jan 28;2023:6991633. doi: 10.1155/2023/6991633. eCollection 2023.
BACKGROUND
Intrapancreatic fat deposition (IPFD) usually occurs in individuals with type 2 diabetes mellitus (T2DM), but its physiopathological influence remains controversial. The present study aimed to investigate IPFD and its associations with various aspects of glucose and lipid metabolism in individuals with newly diagnosed T2DM.
METHODS
A total of 100 individuals were included, consisting of 80 patients with newly diagnosed T2DM and 20 age- and sex-matched healthy controls. Then, we assessed IPFD using magnetic resonance imaging (MRI) and various parameters of glucose and lipid metabolism.
RESULTS
Individuals with newly diagnosed T2DM had a significantly higher IPFD (median: 12.34%; IQR, 9.19-16.60%) compared with healthy controls (median: 6.35%; IQR, 5.12-8.96%) ( < 0.001). In individuals with newly diagnosed T2DM, IPFD was significantly associated with FINS and HOMA-IR in unadjusted model ( = 0.239, =0.022; = 0.578, =0.007, respectively) and adjusted model for age and sex ( = 0.241, =0.022; = 0.535, =0.014, respectively), but these associations vanished after adjustment for age, sex, and BMI. The OR of lower HDL-C for the prevalence of high IPFD was 4.22 (95% CI, 1.41 to 12.69; =0.010) after adjustment for age, sex, BMI, and HbA1c.
CONCLUSIONS
Lower HDL-C was an independent predictor for a high degree of IPFD.
背景
胰腺内脂肪沉积（IPFD）通常发生于2型糖尿病（T2DM）患者中，但其生理病理影响仍存在争议。本研究旨在调查新诊断T2DM患者的IPFD及其与糖脂代谢各方面的关联。
方法
共纳入100例个体，包括80例新诊断的T2DM患者和20例年龄及性别匹配的健康对照。然后，我们使用磁共振成像（MRI）评估IPFD以及糖脂代谢的各项参数。
结果
新诊断的T2DM患者的IPFD显著高于健康对照（中位数：12.34%；四分位数间距，9.19 - 16.60%）（中位数：6.35%；四分位数间距，5.12 - 8.96%）（<0.001）。在新诊断的T2DM患者中，IPFD在未校正模型中与空腹胰岛素（FINS）和稳态模型评估的胰岛素抵抗（HOMA-IR）显著相关（分别为r = 0.239，P = 0.022；r = 0.578，P = 0.007），在年龄和性别校正模型中也显著相关（分别为r = 0.241，P = 0.022；r = 0.535，P = 0.014），但在年龄、性别和体重指数（BMI）校正后这些关联消失。在校正年龄、性别、BMI和糖化血红蛋白（HbA1c）后，高密度脂蛋白胆固醇（HDL-C）降低的情况下高IPFD患病率的比值比（OR）为4.22（95%可信区间，1.41至12.69；P = 0.010）。
结论
HDL-C降低是高度IPFD的独立预测因素。
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