点击和光释双重功能核酸纳米结构。
Click and photo-release dual-functional nucleic acid nanostructures.
机构信息
The RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA.
Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
出版信息
Chem Commun (Camb). 2019 Aug 21;55(65):9709-9712. doi: 10.1039/c9cc03806j. Epub 2019 Jul 29.
Abstract
We functionalize nucleic acid nanostructures with click chemistry (for attachment of cargos) and a photocleavable linker (for release). We demonstrate cargo attachment using a fluorescein dye and release using UV trigger from an RNA three-way junction, a DNA star motif and a DNA tetrahedron. Such multifunctional nucleic acid nanostructures have potential in targeted drug delivery.
摘要
我们使用点击化学（用于连接负载物）和光可裂解连接子（用于释放）对核酸纳米结构进行功能化。我们使用荧光染料进行负载物连接，并使用 RNA 三链结、DNA 星型结构和 DNA 四面体的 UV 触发进行释放。这种多功能核酸纳米结构在靶向药物输送方面具有潜力。
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