SMDZ in Zabrze, Medical University of Silesia, Katowice, Poland.
Department of Cardiology, Silesian Center for Heart Diseases, Zabrze, Poland.
Europace. 2019 Oct 1;21(10):1603-1604. doi: 10.1093/europace/euz163.
Despite major therapeutic advances over the last decades, complex supraventricular and ventricular arrhythmias (VAs), particularly in the emergency setting or during revascularization for acute myocardial infarction (AMI), remain an important clinical problem. Although the incidence of VAs has declined in the hospital phase of acute coronary syndromes (ACS), mainly due to prompt revascularization and optimal medical therapy, still up to 6% patients with ACS develop ventricular tachycardia and/or ventricular fibrillation within the first hours of ACS symptoms. Despite sustained VAs being perceived predictors of worse in-hospital outcomes, specific associations between the type of VAs, arrhythmia timing, applied treatment strategies and long-term prognosis in AMI are vague. Atrial fibrillation (AF) is the most common supraventricular tachyarrhythmia that may be asymptomatic and/or may be associated with rapid haemodynamic deterioration requiring immediate treatment. It is estimated that over 20% AMI patients may have a history of AF, whereas the new-onset arrhythmia may occur in 5% patients with ST elevation myocardial infarction. Importantly, patients who were treated with primary percutaneous coronary intervention for AMI and developed AF have higher rates of adverse events and mortality compared with subjects free of arrhythmia. The scope of this position document is to cover the clinical implications and pharmacological/non-pharmacological management of arrhythmias in emergency presentations and during revascularization. Current evidence for clinical relevance of specific types of VAs complicating AMI in relation to arrhythmia timing has been discussed.
尽管在过去几十年中取得了重大治疗进展,但复杂的室上性和室性心律失常(VA),特别是在紧急情况下或急性心肌梗死(AMI)再血管化期间,仍然是一个重要的临床问题。尽管急性冠状动脉综合征(ACS)的医院阶段 VA 的发生率有所下降,主要是由于及时再血管化和最佳药物治疗,但仍有高达 6%的 ACS 患者在 ACS 症状出现后的头几个小时内发生室性心动过速和/或心室颤动。尽管持续性 VA 被认为是预后不良的预测因素,但在 AMI 中,VA 的类型、心律失常发生时间、应用的治疗策略和长期预后之间的具体关联尚不清楚。房颤(AF)是最常见的室上性心动过速,可能无症状,也可能与需要立即治疗的快速血液动力学恶化有关。据估计,超过 20%的 AMI 患者可能有 AF 病史,而新发心律失常可能发生在 5%的 ST 段抬高型心肌梗死患者中。重要的是,与无心律失常的患者相比,接受 AMI 经皮冠状动脉介入治疗并发生 AF 的患者发生不良事件和死亡的风险更高。本立场文件的范围是涵盖心律失常在紧急情况下和再血管化期间的临床意义和药物/非药物管理。讨论了与心律失常发生时间相关的 AMI 并发特定类型 VA 的临床相关性的现有证据。