术中对明胶基止血剂的过敏反应：一例报告
Intraoperative anaphylaxis to gelatin-based hemostatic agents: a case report.
作者信息
Lied Gülen Arslan, Lund Kjetil Børve, Storaas Torgeir
机构信息
Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Section of Clinical Allergy, Department of Occupational Diseases.
出版信息
J Asthma Allergy. 2019 Jun 18;12:163-167. doi: 10.2147/JAA.S202784. eCollection 2019.
Abstract
Surgiflo Haemostatic Matrix is an absorbable gelatin matrix hemostatic material that has been widely used in various surgical operations to assist hemostasis. Nonetheless, as biologically active agents (contains porcine gelatin), there is potential for allergic reactions to these products. Here, we report the case of a 71-year-old man who had intraoperative anaphylaxis with cardiovascular events to gelatin associated with the use of a topical hemostatic agent (Surgiflo). The patient reported a history of red meat allergy and tick bites during his allergological examination after anaphylaxis. He also had high levels of specific IgE antibodies towards alpha-gal. Special consideration should be given before administering bovine- or porcine-derived gelatin products during surgery to patients with animal-related allergies, such as alpha-gal or gelatin allergy and an atopic background.
摘要
速即纱止血基质是一种可吸收的明胶基质止血材料，已广泛应用于各种外科手术中以辅助止血。然而，作为生物活性剂（含有猪明胶），这些产品存在过敏反应的可能性。在此，我们报告一例71岁男性患者，在使用局部止血剂（速即纱）时发生与明胶相关的术中过敏反应及心血管事件。该患者在过敏反应后进行的变态反应学检查中报告有红肉过敏和蜱叮咬史。他还对α-半乳糖有高水平的特异性IgE抗体。对于有动物相关过敏（如α-半乳糖或明胶过敏以及特应性背景）的患者，在手术期间使用牛或猪源明胶产品之前应特别考虑。
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