Department of Chemistry, Technical University of Denmark, Kongens Lyngby, Denmark.
Division of Rheumatology, Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, United States.
Front Immunol. 2019 Jul 9;10:1487. doi: 10.3389/fimmu.2019.01487. eCollection 2019.
Skin autoimmune conditions belong to a larger group of connective tissue diseases and primarily affect the skin, but might also involve underlying tissues, such as fat tissue, muscle, and bone. Autoimmune antibodies (autoantibodies) play a role in autoimmune skin diseases, such as localized scleroderma also termed morphea, and systemic scleroderma, also called systemic sclerosis (SSc). The detailed studies on the biological role of autoantibodies in autoimmune skin diseases are limited. This results in a few available tools for effective diagnosis and management of autoimmune skin diseases. This review aims to provide an update on the detection and most recent research on autoantibodies in morphea. Several recent studies have indicated the association of autoantibody profiles with disease subtypes, damage extent, and relapse potential, opening up exciting new possibilities for personalized disease management. We discuss the role of existing autoantibody tests in morphea management and the most recent studies on morphea pathogenesis. We also provide an update on novel autoantibody biomarkers for the diagnosis and study of morphea.
皮肤自身免疫性疾病属于一组较大的结缔组织疾病，主要影响皮肤，但也可能涉及潜在组织，如脂肪组织、肌肉和骨骼。自身抗体（自身抗体）在自身免疫性皮肤病中起作用，例如局限性硬皮病也称为硬斑病，和系统性硬皮病，也称为系统性硬化症（SSc）。对自身抗体在自身免疫性皮肤病中的生物学作用的详细研究是有限的。这导致了一些可用的工具来有效诊断和管理自身免疫性皮肤病。这篇综述旨在提供硬斑病自身抗体检测和最新研究的最新信息。一些最近的研究表明，自身抗体谱与疾病亚型、损伤程度和复发潜力有关，为个性化疾病管理开辟了令人兴奋的新可能性。我们讨论了现有自身抗体检测在硬斑病管理中的作用以及硬斑病发病机制的最新研究。我们还提供了用于硬斑病诊断和研究的新型自身抗体生物标志物的最新信息。
