Cassalia Fortunato, Federico Serena, Danese Andrea, Franceschin Ludovica, Amato Simone, Gratteri Francesco, Battilotti Chiara, Caroppo Francesca, Zappia Elena, Bennardo Luigi, Belloni Fortina Anna, Nisticò Steven Paul
Unit of Dermatology, Department of Medicine, University of Padua, 35121 Padua, Italy.
Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy.
J Pers Med. 2024 Aug 17;14(8):872. doi: 10.3390/jpm14080872.
Localized scleroderma (LS), commonly known as morphea, presents a significant clinical challenge due to its chronic, inflammatory nature affecting the skin and potentially underlying tissues. This systematic review explores the innovative approach of combining laser therapy and injectable fillers, specifically hyaluronic acid, for the treatment of LS. We conducted a comprehensive literature review following PRISMA guidelines, examining articles from MEDLINE/PubMed to assess the combined efficacy of these treatments in improving both esthetic and functional outcomes for LS patients. The search yielded 64 articles, with six selected for in-depth analysis for a total of nine patients, covering a range of patient demographics and treatment types. Our review highlights cases where fractional CO laser therapy promoted long-term tissue remodeling and instances where hyaluronic acid fillers effectively addressed skin atrophy and volume loss, enhancing both immediate and long-lasting esthetic improvements. The synergy between these treatments suggests a promising dual approach, aiming to maximize esthetic outcomes and to improve the quality of life for LS patients. This review underscores the necessity of further research to establish a comprehensive, evidence-based clinical pathway integrating both treatments for managing LS, thereby enhancing patient satisfaction and addressing the multifaceted nature of this challenging dermatological condition.
局限性硬皮病（LS），通常称为硬斑病，因其慢性、炎症性本质影响皮肤及潜在的深层组织，带来了重大的临床挑战。本系统评价探讨了将激光治疗与可注射填充剂（特别是透明质酸）相结合治疗局限性硬皮病的创新方法。我们按照PRISMA指南进行了全面的文献综述，查阅了MEDLINE/PubMed数据库中的文章，以评估这些治疗方法联合使用在改善局限性硬皮病患者美学和功能结局方面的疗效。检索共得到64篇文章，从中筛选出6篇进行深入分析，涉及9名患者，涵盖了不同的患者特征和治疗类型。我们的综述强调了分次二氧化碳激光治疗促进长期组织重塑的案例，以及透明质酸填充剂有效解决皮肤萎缩和容积丧失、实现即时和持久美学改善的案例。这些治疗方法之间的协同作用表明了一种有前景的双重治疗方法，旨在最大化美学效果并改善局限性硬皮病患者的生活质量。本综述强调了进一步研究的必要性，以建立一个综合的、基于证据的临床路径，将这两种治疗方法整合用于局限性硬皮病的管理，从而提高患者满意度，并应对这种具有挑战性的皮肤病的多方面特性。
