人源化抗肝细胞生长因子单克隆抗体（YYB-101）抑制卵巢癌进展。

Humanized Anti-hepatocyte Growth Factor Monoclonal Antibody (YYB-101) Inhibits Ovarian Cancer Progression.

作者信息

Kim Hyun Jung, Lee Sukmook, Oh Yong-Seok, Chang Ha Kyun, Kim Young Sang, Hong Sung Hee, Kim Jung Yong, Park Young-Whan, Lee Song-Jae, Song Seong-Won, Kim Jung Ju, Heo Kyun

机构信息

Research Institute, National Cancer Center, Goyang-si, South Korea.

Department of Bioinspired Science, Ewha Womans University, Seoul, South Korea.

出版信息

Front Oncol. 2019 Jul 9;9:571. doi: 10.3389/fonc.2019.00571. eCollection 2019.

Current chemotherapy regimens have certain limitations in improving the survival rates of patients with advanced ovarian cancer. Hepatocyte growth factor (HGF) is important in ovarian cancer cell migration and invasion. This study assessed the effects of YYB-101, a humanized monoclonal anti-HGF antibody, on the growth and metastasis of ovarian cancer cells. YYB-101 suppressed the phosphorylation of the HGF receptor c-MET and inhibited the migration and invasion of SKOV3 and A2780 ovarian cancer cells. Moreover, the combination of YYB-101 and paclitaxel synergistically inhibited tumor growth in an ovarian cancer mouse xenograft model and significantly increased the overall survival (OS) rate compared with either paclitaxel or YYB-101 alone. Taken together, these findings suggest that YYB-101 has therapeutic potential in ovarian cancer when combined with conventional chemotherapy agents.