Institute of Molecular Biology (IMB), Mainz, Germany.
EMBO J. 2019 Aug 15;38(16):e102871. doi: 10.15252/embj.2019102871. Epub 2019 Jul 29.
In response to DNA damage, transient repair compartments in the nucleus concentrate repair proteins and activate downstream signaling factors. In this issue of The EMBO Journal, Kilic et al show that DNA repair focal assemblies marked by accumulation of 53BP1 are phase separated liquid compartments. This liquid droplet-like behavior of 53BP1 compartments might help to coordinate local lesion recognition with global gene activation in response to DNA damage.
针对 DNA 损伤，细胞核中的瞬时修复隔室集中修复蛋白并激活下游信号转导因子。在本期《欧洲分子生物学组织杂志》中，基利奇等人表明，由 53BP1 积累标记的 DNA 修复焦点组装是相分离的液体隔室。53BP1 隔室的这种类似液滴的行为可能有助于协调局部损伤识别与 DNA 损伤响应中的全局基因激活。
