基于羧基化石墨烯量子点的智能药物递送纳米系统用于肿瘤靶向化疗。
A smart drug-delivery nanosystem based on carboxylated graphene quantum dots for tumor-targeted chemotherapy.
机构信息
College of Biology, Hunan Province Key Laboratory of Plant Functional Genomics & Developmental Regulation, Hunan University, Changsha, 410082, PR China.
TCM & Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, PR China.
出版信息
Nanomedicine (Lond). 2019 Aug;14(15):2011-2025. doi: 10.2217/nnm-2018-0378. Epub 2019 Jul 29.
Constructing a new drug-delivery system using carboxylated graphene quantum dots (cGQDs) for tumor chemotherapy . A drug-delivery system was synthesized through a crosslink reaction of cGQDs, NH-poly(ethylene glycol)-NH and folic acid. A drug delivery system of folic acid-poly(ethylene glycol)-cGQDs was successfully constructed with ideal entrapment efficiency (97.5%) and drug-loading capacity (40.1%). Cell image indicated that the nanosystem entered into human cervical cancer cells mainly through macropinocytosis-dependent pathway. experiments showed the outstanding antitumor ability and low systemic toxicity of this nanodrug-delivery system. The newly developed drug-delivery system provides an important alternative for tumor therapy without causing systemic adverse effects.
使用羧基化石墨烯量子点（cGQDs）构建新型药物递送系统用于肿瘤化疗。通过 cGQDs、NH-聚（乙二醇）-NH 和叶酸的交联反应合成了药物递送系统。成功构建了叶酸-聚（乙二醇）-cGQDs 的药物递送系统，具有理想的包封效率（97.5%）和载药能力（40.1%）。细胞图像表明，纳米系统主要通过巨胞饮作用依赖性途径进入人宫颈癌细胞。实验表明，这种纳米药物递送系统具有优异的抗肿瘤能力和低全身毒性。新开发的药物递送系统为肿瘤治疗提供了一种重要的替代方法，而不会引起全身不良反应。
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