Medical Bionanotechnology, Faculty of Allied Health Sciences, Chettinad Hospital & Research Institute (CHRI), Chettinad Academy of Research & Education (CARE), Kelambakkam, Chennai 603103, India.
Nanomedicine (Lond). 2019 Aug;14(15):2067-2082. doi: 10.2217/nnm-2019-0155. Epub 2019 Jul 29.
Owing to the limitations of conventional therapies, there has been an increasing need for nanomedicines for real-time diagnosis and effective treatment of life-threatening diseases. Despite the conceptual and technological success achieved by researchers worldwide, the complexities of biological systems, efficient engineering and formulation of monodispersed nanomedicines, inadequate information on bio-nano interactions, issues on health hazards, clinical trials and commercialization have set new challenges in biomedical research. This review highlights how the biological membrane improves the performance of nanomedicines in drug delivery. With the list of nanomedicines getting longer gradually to overcome the drawbacks of conventional therapeutics, it is important to concentrate on the interactions between nanostructures and living systems in order to improve the biocompatibility and therapeutic efficacy of functional nanomedicines.
由于传统疗法的局限性，人们越来越需要纳米药物来实时诊断和有效治疗危及生命的疾病。尽管世界各地的研究人员在概念和技术上都取得了成功，但生物系统的复杂性、单分散纳米药物的高效工程和配方、生物-纳米相互作用信息不足、健康危害问题、临床试验和商业化等问题都给生物医学研究带来了新的挑战。本文综述了生物膜如何提高纳米药物在药物传递中的性能。随着纳米药物清单的逐渐增加，以克服传统治疗的缺点，重要的是要集中研究纳米结构与生命系统之间的相互作用，以提高功能纳米药物的生物相容性和治疗效果。
