Gowtham Pemula, Girigoswami Koyeli, Pallavi Pragya, Harini Karthick, Gurubharath Ilangovan, Girigoswami Agnishwar
Medical Bionanotechnology, Faculty of Allied Health Sciences, Chettinad Hospital & Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), Kelambakkam, Chennai 603103, India.
Department of Radiology, Chettinad Hospital & Research Institute (CHRI), Chettinad Academy of Research and Education (CARE), Kelambakkam, Chennai 603103, India.
Pharmaceutics. 2022 Nov 22;14(12):2550. doi: 10.3390/pharmaceutics14122550.
Carbon-decorated ferrite nanodots (MNF@Cs) have been enhanced with superparamagnetism and higher fluorescence quantum yield by encapsulation with an alginate derivative to create a cost-effective and less toxic multimodal contrast agent for replacing the conventional heavy metal Gd-containing contrast agent used in MR imaging. The novel surface-engineered particles (MNF@C-OSAs), devoid of labels, can simultaneously provide both longitudinal and transverse relaxation-based magnetic resonance imaging (MRI) and fluorescence emission. According to the findings of in vitro studies, the calculated molar relaxivities and the molar radiant efficiencies are indicative of the multimodal efficacy of MNF@C-OSA as compared with MNF@C particles and conventional contrast agents used in medical imaging. MNF@C-OSAs were shown to be significantly biocompatible and negligibly toxic when assessed against A549 cells and zebrafish embryos, indicating their potential for use as theranostic agents.
通过用藻酸盐衍生物封装，碳修饰的铁氧体纳米点（MNF@Cs）的超顺磁性和荧光量子产率得到了增强，从而制备出一种经济高效且毒性较小的多模态造影剂，以替代磁共振成像中使用的传统含重金属钆造影剂。这种新型的表面工程化颗粒（MNF@C-OSAs）没有标记物，能够同时提供基于纵向和横向弛豫的磁共振成像（MRI）以及荧光发射。根据体外研究结果，与MNF@C颗粒和医学成像中使用的传统造影剂相比，计算得出的摩尔弛豫率和摩尔辐射效率表明了MNF@C-OSA的多模态功效。在针对A549细胞和斑马鱼胚胎进行评估时，MNF@C-OSAs显示出显著的生物相容性且毒性可忽略不计，这表明它们有作为治疗诊断剂的潜力。
