Shandong Yantai Nursing School, Yantai, Shandong, China.
Department of Neurology, Yantaishan Hospital, Yantai, Shandong, China.
J Vestib Res. 2019;29(2-3):131-136. doi: 10.3233/VES-190669.
Persistent postural-perceptual dizziness (PPPD) is a chronic dizziness, its pathogenesis is unknown by now.
To study the relationship between the DRD2 gene TaqIA polymorphisms and PPPD, and further to explore the molecular mechanism underlying this disease.
43 patients diagnosed with PPPD and 45 randomly selected cases (matched by age and sex) were included in the study and control group, respectively. DRD2 gene TaqIA polymorphisms were detected in all participants by polymerase chain reaction (PCR)combined with the restriction fragment length polymorphism (RFLP) method.
In the study group, frequencies of the A1 and A2 TaqIA alleles (65.1% and 34.9%, respectively) were significantly different to those in the control group (46.7% and 53.3%, respectively; P < 0.05). The allele frequency in the study group for the A1/A1 genotype was 34.9%, for A1/A2 was 60.5%, and for A2/A2 was 4.6%, all of which were significantly higher than the control group (24.4%, 44.5%. and 31.1%, respectively; P < 0.01).
Our findings indicate that the DRD2 TaqIA A1 allele is possibly the susceptibility polymorphism for PPPD, and that the A2/A2 genotype has a potentially protective role for PPPD. However, larger independent studies are required for further validation.
持续性姿势-感知性头晕（PPPD）是一种慢性头晕，其发病机制尚不清楚。
研究 DRD2 基因 TaqIA 多态性与 PPPD 的关系，并进一步探讨该病的分子机制。
将 43 例 PPPD 患者和 45 例随机选择的病例（按年龄和性别匹配）分别纳入研究组和对照组，采用聚合酶链反应（PCR）结合限制性片段长度多态性（RFLP）方法检测所有参与者的 DRD2 基因 TaqIA 多态性。
在研究组中，A1 和 A2 TaqIA 等位基因（分别为 65.1%和 34.9%）的频率明显不同于对照组（分别为 46.7%和 53.3%；P<0.05）。研究组 A1/A1 基因型的等位基因频率为 34.9%，A1/A2 为 60.5%，A2/A2 为 4.6%，均明显高于对照组（分别为 24.4%、44.5%和 31.1%；P<0.01）。
我们的研究结果表明，DRD2 TaqIA A1 等位基因可能是 PPPD 的易感多态性，A2/A2 基因型可能对 PPPD 具有潜在的保护作用。然而，需要更大的独立研究来进一步验证。
