Pangalis G A, Moutsopoulos H M, Papadopoulos N M, Costello R, Kokkinou S, Fessas P
First Department of Internal Medicine, University of Athens School of Medicine, Greece.
Acta Haematol. 1988;80(1):23-7. doi: 10.1159/000205593.
The incidence of monoclonal and oligoclonal immunoglobulins (paraproteins) was determined in serum samples of 45 chronic lymphocytic leukemia (B-CLL) patients using the high-resolution agarose gel electrophoresis technique combined with immunofixation. Paraproteins were identified in 25 of the 45 patients tested. Twelve paraproteins were monoclonal and 13 oligoclonal. IgG kappa and/or lambda immunoglobulin isotypes were found in 17/25 of these patients. No correlation of the lymphocyte cell morphology and the presence of paraproteins was demonstrated. The high frequency of serum oligoclonal immunoglobulins in B-CLL indicates that more than one lymphocyte clone may be present in this disease.
采用高分辨率琼脂糖凝胶电泳技术结合免疫固定法，测定了45例慢性淋巴细胞白血病（B-CLL）患者血清样本中单克隆和寡克隆免疫球蛋白（副蛋白）的发生率。在45例接受检测的患者中，有25例鉴定出副蛋白。其中12例为单克隆副蛋白，13例为寡克隆副蛋白。在这些患者中有17/25检测到IgG κ和/或λ免疫球蛋白亚型。未证实淋巴细胞细胞形态与副蛋白的存在之间存在相关性。B-CLL患者血清寡克隆免疫球蛋白的高频率表明，该疾病中可能存在不止一个淋巴细胞克隆。
