Discovery of Two New Sorbicillinoids by Overexpression of the Global Regulator LaeA in a Marine-Derived Fungus YJ-11.

Overexpression of the global regulator LaeA in a marine-derived fungal strain of YJ-11 induced obvious morphological changes and metabolic variations. Further chemical investigation of the mutant strain afforded a series of sorbicillinoids including two new ones named 10,11-dihydrobislongiquinolide () and 10,11,16,17-tetrahydrobislongiquinolide (), as well as four known analogues, bislongiquinolide (), 16,17-dihydrobislongiquinolide (), sohirnone A (), and 2',3'-dihydrosorbicillin (). The results support that the global regulator LaeA is a useful tool in activating silent gene clusters in strains to obtain previously undiscovered compounds.