海洋来源青霉属真菌次生代谢产物的起源、结构及生物活性

Origins, Structures, and Bioactivities of Secondary Metabolites from Marine-derived Penicillium Fungi.

作者信息

Yang Xiliang, Liu Jinping, Mei Jiahui, Jiang Rui, Tu Shizheng, Deng Huafeng, Liu Jing, Yang Sumei, Li Juan

机构信息

Department of Pharmacy, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Institute of Infection, Immunology and Tumor Microenvironments, Medical College, Wuhan University of Science and Technology, Wuhan 430081, China.

Department of Pharmacy, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

出版信息

Mini Rev Med Chem. 2021;21(15):2000-2019. doi: 10.2174/1389557521666210217093517.

DOI:10.2174/1389557521666210217093517

PMID:33596801

Abstract

In recent years, marine-derived Penicillium fungi have received remarkable interest as a valuable source of novel natural products encompassing diverse chemical structures and bioactive properties. Mangroves, sediments, algae, and sponges are the four main sources of marine-derived Penicillium fungi. As of 2014, more than 390 novel natural products have been isolated from the marine- derived Penicillium fungi, mainly including polyketides, alkaloids, terpenoids, and macrolides. Biological investigations have shown that these compounds possess antimicrobial, anti-inflammatory, cytotoxic, and other activities with potential applications in new drug development. To provide an updated catalog of this field, our mini-review summarized the origins, structures, and bioactivities of 188 secondary metabolites from marine-derived Penicillium fungi based on bioactivities classification published from 2015 to 2020.

摘要

近年来，源自海洋的青霉菌作为新型天然产物的宝贵来源受到了极大关注，这些天然产物具有多样的化学结构和生物活性。红树林、沉积物、藻类和海绵是源自海洋的青霉菌的四个主要来源。截至2014年，已从源自海洋的青霉菌中分离出390多种新型天然产物，主要包括聚酮化合物、生物碱、萜类化合物和大环内酯类化合物。生物学研究表明，这些化合物具有抗菌、抗炎、细胞毒性等活性，在新药开发中具有潜在应用价值。为了提供该领域的最新目录，我们的小型综述基于2015年至2020年发表的生物活性分类，总结了源自海洋的青霉菌188种次生代谢产物的来源、结构和生物活性。