Yasenchuk Yuri, Marchenko Ekaterina, Gunther Victor, Radkevich Andrey, Kokorev Oleg, Gunther Sergey, Baigonakova Gulsharat, Hodorenko Valentina, Chekalkin Timofey, Kang Ji-Hoon, Weiss Sabine, Obrosov Aleksei
Research Institute of Medical Materials, Tomsk State University, Tomsk 634045, Russia.
Research Institute of Medical Problems of the North, Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk 660017, Russia.
Materials (Basel). 2019 Jul 28;12(15):2405. doi: 10.3390/ma12152405.
Porous TiNi alloys fabricated by self-propagating high-temperature synthesis (SHS) are biomaterials designed for medical application in substituting tissue lesions and they were clinically deployed more than 30 years ago. The SHS process, as a very fast and economically justified route of powder metallurgy, has distinctive features which impart special attributes to the resultant implant, facilitating its integration in terms of bio-mechanical/chemical compatibility. On the phenomenological level, the fact of high biocompatibility of porous SHS TiNi (PTN) material in vivo has been recognized and is not in dispute presently, but the rationale is somewhat disputable. The features of the SHS TiNi process led to a multifarious intermetallic TiNi(O,N,C)-based constituents in the amorphous-nanocrystalline superficial layer which entirely conceals the matrix and enhances the corrosion resistance of the unwrought alloy. In the current article, we briefly explore issues of the high biocompatibility level on which additional studies could be carried out, as well as recent progress and key fields of clinical application, yet allowing innovative solutions.
通过自蔓延高温合成（SHS）制备的多孔钛镍合金是用于替代组织损伤的医学应用生物材料，30多年前已临床应用。SHS工艺作为一种非常快速且经济合理的粉末冶金路线，具有独特的特性，这些特性赋予了所得植入物特殊属性，有利于其在生物力学/化学兼容性方面的整合。从现象学层面来看，多孔SHS钛镍（PTN）材料在体内具有高生物相容性这一事实已得到认可，目前并无争议，但其中的原理存在一定争议。SHS钛镍工艺的特性导致在非晶 - 纳米晶表层中形成了多种基于金属间化合物TiNi(O,N,C)的成分，这些成分完全覆盖了基体并提高了未加工合金的耐腐蚀性。在本文中，我们简要探讨了可以进行更多研究的高生物相容性水平问题，以及近期进展和临床应用的关键领域，同时也考虑了创新解决方案。
