通过储存操纵的 CRAC 通道的钙微区信号传导。
Signaling through Ca Microdomains from Store-Operated CRAC Channels.
机构信息
Department of Physiology, Anatomy, and Genetics, Oxford University, Oxford OX1 3PT, United Kingdom.
出版信息
Cold Spring Harb Perspect Biol. 2020 Jul 1;12(7):a035097. doi: 10.1101/cshperspect.a035097.
Abstract
Calcium (Ca) ion microdomains are subcellular regions of high Ca concentration that develop rapidly near open Ca channels in the plasma membrane or internal stores and generate local regions of high Ca concentration. These microdomains are remarkably versatile in that they activate a range of responses that differ enormously in both their temporal and spatial profile. In this review, we describe how Ca microdomains generated by store-operated calcium channels, a widespread and conserved Ca entry pathway, stimulate different signaling pathways, and how the spatial extent of a Ca microdomain can be influenced by Ca ATPase pumps.
摘要
钙离子微域是细胞内钙离子浓度较高的区域，在质膜上的开放钙离子通道或内部储存器附近迅速形成，并产生局部高钙离子浓度区域。这些微域非常多样化，它们激活的一系列反应在时间和空间特征上有很大的不同。在这篇综述中，我们描述了由储存操纵钙通道产生的钙离子微域如何刺激不同的信号通路，以及钙 ATP 酶泵如何影响钙离子微域的空间范围。
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