苯并(a)芘与肺和胸腺细胞核组分的结合。
Binding of benzo(a)pyrene into lung and thymocyte nuclear fractions.
作者信息
Blazsek I, Vauhkonen M, Hemminki K
出版信息
Res Commun Chem Pathol Pharmacol. 1979 Mar;23(3):611-26.
Binding of (3H)benzo(a)pyrene into lung and thymocyte nuclear fractions is studied in short term cultures. DNA, RNA and protein in the subnuclear fractions is separated and tightly bound radioactivity is measured. Among the fractions, proteins of the matrix sediment fraction display the highest specific radioactivity. DNA has a low specific radioactivity as compared to that of RNA and protein in all fractions. In thymocyte matrix extract and chromatin fractions the specific radioactivity of RNA exceeds that of protein. Lung nonhistones display a 30 times higher specific radioactivity as compared to histones. The corresponding ratio of the thymocyte fractions is about 10.
在短期培养中研究了（3H）苯并（a）芘与肺和胸腺细胞核组分的结合。分离亚核组分中的DNA、RNA和蛋白质，并测量紧密结合的放射性。在这些组分中，基质沉淀组分的蛋白质显示出最高的比放射性。与所有组分中的RNA和蛋白质相比，DNA的比放射性较低。在胸腺细胞基质提取物和染色质组分中，RNA的比放射性超过蛋白质。肺非组蛋白的比放射性比组蛋白高30倍。胸腺细胞组分的相应比例约为10。
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