Bertozzi Giuseppe, Sessa Francesco, Maglietta Francesca, Cipolloni Luigi, Salerno Monica, Fiore Carmela, Fortarezza Palmira, Ricci Pietrantonio, Turillazzi Emanuela, Pomara Cristoforo
Department of Clinical and Experimental Medicine, Section of Legal Medicine, University of Foggia, Viale Pinto, 71122, Foggia, Italy.
Department of Medical, Surgical and Advanced Technologies "G.F. Ingrassia", University of Catania, Catania, Italy.
Forensic Sci Med Pathol. 2019 Dec;15(4):616-621. doi: 10.1007/s12024-019-00144-z. Epub 2019 Jul 29.
Even if there are well-known consequences of anabolic androgenic steroid (AAS) abuse, their full pathway of action is still being investigated. In this context, the presented case report aims to discuss and provide evidence of unusual adverse effects linked to immunodeficiency in an AAS abuser. In fact, this kind of chronic complication, even if not usually considered, may lead sudden death. In this case a 31-year-old aesthetic weightlifter, who presented to the emergency department due to an accidental fall that resulted in left thigh trauma. This subsequently developed into left thigh necrotizing myofasciitis in the following few days. Although surgery and hyperbaric therapy were carried out, the man died. An autopsy with complete biological sampling for toxicological studies was performed. This case highlights the close relationship between AAS abuse and immunodeficiency and highlights it's importance for further studies. However, it should be considered that of all the dangerous effects produced by AAS use, necrotizing fasciitis is not such an unusual consequence.
即使合成代谢雄激素类固醇（AAS）滥用存在众所周知的后果，但其完整的作用途径仍在研究中。在此背景下，本病例报告旨在讨论并提供与一名AAS滥用者免疫缺陷相关的异常不良反应的证据。事实上，这种慢性并发症即使通常未被考虑，也可能导致猝死。在本病例中，一名31岁的健美举重运动员因意外摔倒导致左大腿受伤而被送往急诊科。随后在接下来的几天里发展为左大腿坏死性筋膜炎。尽管进行了手术和高压氧治疗，但该男子仍死亡。进行了尸检并采集了完整的生物样本用于毒理学研究。本病例突出了AAS滥用与免疫缺陷之间的密切关系，并强调了其对进一步研究的重要性。然而，应该考虑到，在AAS使用产生的所有危险影响中，坏死性筋膜炎并非如此不寻常的后果。
