University College of Conventional Medicine, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
Phytother Res. 2019 Oct;33(10):2622-2648. doi: 10.1002/ptr.6447. Epub 2019 Jul 29.
Nardostachys chinensis Batalin (Valerianaceae) has been widely used in different traditional systems of medicine, including Islamic, Ayurvedic, Chinese, and Korean folk medicine. It has been used in traditional medicine as a tranquilizer, hepatotonic, cardiotonic, diuretic, and analgesic. Preliminary in vitro and in vivo studies have provided valuable scientific evidence for its traditional uses. This review aims to summarize reported traditional uses, phytochemistry, and pharmacological potential of N. chinensis while identifying potential areas of further research of plant. The review comprises literature pertaining to the pharmacological potential and phytochemistry of N. chinensis using worldwide accepted scientific databases via electronic search (Elsevier, Google Scholar, Pub Med, Scopus, Springer, Wiley online library). Moreover, data from ethno botanical text books available in library and electronic search were also included. The Plant List and Kew Herbarium Catalogue databases were used to authenticate the scientific name. Different pharmacological experiments in many in vitro and in vivo models have proved the potential of N. chinensis, namely, anti-inflammatory, anticonvulsant, antibacterial, antihypertensive, antifungal, neuroprotective, cardioprotective, aldose reductase inhibition, and antioxidant activities. The plant contains sesquiterpenenes of various varieties including aristolane, guaiane, and nardosinane types. Moreover, it also contains coumarins, phenols, lignans, neolignans, and glycosides. Reported activities suggested that there may be pharmacological potential for developing N. chinensis as a drug for infections, hypertension, cardiac diseases, Alzheimer's disease, insomnia, epilepsy, cancer, gastric, and liver diseases. More toxicological studies should be performed that will aid the progress to clinical trial studies of N. chinensis.
列当科植物（Nardostachys chinensis Batalin）在不同的传统医学体系中被广泛应用，包括伊斯兰医学、阿育吠陀医学、中医和韩国传统医学。它在传统医学中被用作镇静剂、保肝药、强心药、利尿剂和镇痛药。初步的体外和体内研究为其传统用途提供了有价值的科学证据。本综述旨在总结列当的传统用途、植物化学和药理学潜力，同时确定该植物进一步研究的潜在领域。本综述通过电子搜索（Elsevier、Google Scholar、Pub Med、Scopus、Springer、Wiley online library）使用全球公认的科学数据库，收录了有关列当的药理学潜力和植物化学的文献。此外，还包括图书馆和电子搜索中可用的民族植物学教科书的数据。使用“植物名录”和“邱园标本馆目录”数据库来验证植物的学名。许多体外和体内模型的不同药理实验已经证明了列当的潜力，包括抗炎、抗惊厥、抗菌、降压、抗真菌、神经保护、心脏保护、醛糖还原酶抑制和抗氧化活性。该植物含有各种品种的倍半萜烯，包括阿里烷型、愈创木烷型和喇叭烷型。此外，它还含有香豆素、酚类、木脂素、新木脂素和糖苷。已报道的活性表明，列当可能具有开发成抗感染、高血压、心脏病、阿尔茨海默病、失眠、癫痫、癌症、胃病和肝病药物的药理学潜力。应该进行更多的毒理学研究，这将有助于列当的临床试验研究取得进展。
