Liu Xiangyue, Yang Jing, Yu Huijuan, Zhang Jing, Du Jie, Wang Xinhui, Wang Yuefei, Chai Xin
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Nat Prod Res. 2021 Apr;35(7):1071-1076. doi: 10.1080/14786419.2019.1638382. Epub 2019 Jul 30.
Two new compounds, corylifol H () and -bavacoumestan C (), together with a new natural product named 8-geranyl daidzein (), were isolated from the fruits of (L.) Medik. (syn. of L.) by the targeted separation mode. The structures of these compounds were elucidated on the basis of spectroscopic methods and by comparison with literature properties. The anti-inflammatory effects of the two new compounds were also evaluated by activity assay . The results showed that compounds and inhibited nitric oxide production in LPS-activated RAW 264.7 macrophages in a dose dependent manner.
通过靶向分离模式从（L.）Medik.（L.的同义词）的果实中分离出两种新化合物，即紫花前胡醇H（）和β-巴豆香豆素C（），以及一种名为8-香叶基大豆苷元（）的新天然产物。基于光谱方法并与文献性质进行比较，阐明了这些化合物的结构。还通过活性测定评估了这两种新化合物的抗炎作用。结果表明，化合物和以剂量依赖性方式抑制LPS激活的RAW 264.7巨噬细胞中一氧化氮的产生。
