Fila Michał, Pawłowska Elżbieta, Blasiak Janusz
Department of Neurology, Polish Mother Memorial Hospital, Research Institute, Lodz, Poland.
Department of Orthodontics, Medical University of Lodz, Lodz, Poland.
Arch Med Sci. 2019 Jul;15(4):944-956. doi: 10.5114/aoms.2019.86061. Epub 2019 Jun 20.
The approximately three times higher rate of migraine prevalence in women than men may result from the mitochondrial transmission of this disease. Studies with imaging techniques suggest disturbances in mitochondrial metabolism in specific regions of the brain in migraine patients. Migraine shares some clinical features with several mitochondrial diseases and many other disorders include migraine headaches. Epigenetic regulation of mitochondrial DNA (mtDNA) is a matter of debate and there are some conflicting results, especially on mtDNA methylation. Micro RNAs (miRNAs) and long-noncoding RNA (lncRNAs) have been detected in mitochondria. The regulation of the miRNA-lncRNA axis can be important for mitochondrial physiology and its impairment can result in a disease phenotype. Further studies on the role of mitochondrial epigenetic modifications in migraine are needed, but they require new methods and approaches.
女性偏头痛患病率比男性高约三倍，这可能是由于该疾病的线粒体遗传所致。影像学技术研究表明，偏头痛患者大脑特定区域的线粒体代谢存在紊乱。偏头痛与几种线粒体疾病有一些共同的临床特征，许多其他疾病也包括偏头痛性头痛。线粒体DNA（mtDNA）的表观遗传调控存在争议，并且有一些相互矛盾的结果，尤其是关于mtDNA甲基化。线粒体中已检测到微小RNA（miRNA）和长链非编码RNA（lncRNA）。miRNA-lncRNA轴的调控对线粒体生理可能很重要，其受损可能导致疾病表型。需要进一步研究线粒体表观遗传修饰在偏头痛中的作用，但这需要新的方法和途径。
