Zheng Yafang, Jin Jing, Wei Chuanxiang, Huang Chunyuan
Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China.
Front Nutr. 2024 Jun 18;11:1412031. doi: 10.3389/fnut.2024.1412031. eCollection 2024.
An antioxidant-rich diet has been shown to protect against migraines in previous research. However, little has been discovered regarding the association between migraines and vitamin C (an essential dietary antioxidant). This study assessed the dietary vitamin C intake among adult migraineurs in the United States to determine if there is a correlation between migraine incidence and vitamin C consumption in adults.
This cross-sectional research encompassed adults who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2004, providing detailed information on their dietary vitamin C intake as well as their history of severe headaches or migraines. The study used weighted multivariable and logistic regression analyses to find an independent connection between vitamin C consumption and severe headache or migraine. Tests of interactions and subgroup analysis were conducted.
Among the 13,445 individuals in the sample, 20.42% had a severe headache or migraine. In fully adjusted models, dietary vitamin C consumption was substantially linked negatively with severe headache or migraine (odds ratio [OR] = 0.94, 95% confidence interval [CI] = 0.91-0.98, = 0.0007). Compared to quartile 1, quartile 4 had 22% fewer odds of having a severe headache or migraine (OR = 0.78, 95% CI = 0.69-0.89, = 0.0002). Subgroup analyses showed a significant difference between vitamin C intake and severe headaches or migraines by gender ( for interaction < 0.01).
Reduced risk of severe headaches or migraines may be associated with increased consumption of vitamin C.
先前的研究表明，富含抗氧化剂的饮食可预防偏头痛。然而，关于偏头痛与维生素C（一种必需的膳食抗氧化剂）之间的关联，目前发现的较少。本研究评估了美国成年偏头痛患者的膳食维生素C摄入量，以确定成人偏头痛发病率与维生素C摄入量之间是否存在相关性。
这项横断面研究涵盖了1999年至2004年参加美国国家健康和营养检查调查（NHANES）的成年人，他们提供了有关膳食维生素C摄入量以及严重头痛或偏头痛病史的详细信息。该研究使用加权多变量和逻辑回归分析来寻找维生素C摄入量与严重头痛或偏头痛之间的独立关联。进行了交互作用检验和亚组分析。
在样本中的13445名个体中，20.42%患有严重头痛或偏头痛。在完全调整的模型中，膳食维生素C摄入量与严重头痛或偏头痛呈显著负相关（优势比[OR]=0.94，95%置信区间[CI]=0.91-0.98，P=0.0007）。与第一四分位数相比，第四四分位数发生严重头痛或偏头痛的几率低22%（OR=0.78，95%CI=0.69-0.89，P=0.0002）。亚组分析显示，按性别划分，维生素C摄入量与严重头痛或偏头痛之间存在显著差异（交互作用P<0.01）。
严重头痛或偏头痛风险的降低可能与维生素C摄入量的增加有关。
