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唐氏综合征合并心包积液的短暂异常骨髓生成：病例报告

Transient abnormal myelopoiesis with pericardial effusion in Down syndrome: Case report.

作者信息

Falasco Bianca Francisco, Durante Brenda, Faria Daniel Kanaan, Faria Caroline Silvério, Rosolen Débora Cristina Batista, Antonangelo Leila

机构信息

Divisao de Patologia Clinica - Departamento de Patologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina Universidade de Sao Paulo Sao Paulo SP Brazil.

Laboratorio de Investigacao Medica (LIM 03), Faculdade de Medicina FMUSP Universidade de Sao Paulo Sao Paulo SP Brazil.

出版信息

Clin Case Rep. 2019 May 17;7(7):1280-1284. doi: 10.1002/ccr3.2184. eCollection 2019 Jul.

DOI:10.1002/ccr3.2184
PMID:31360467
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6637340/
Abstract

Pericardial effusion associated with transient abnormal myelopoiesis in Down's syndrome neonates needs to be diagnosed in a timely manner, and the comorbidities must be treated to prevent mortality. To our knowledge, the occurrence of basophilic/eosinophilic pericardial effusion without an increase of these cells in the peripheral blood and with no evidence of associated hypothyroidism is rare.

摘要

唐氏综合征新生儿中与短暂异常骨髓造血相关的心包积液需要及时诊断，必须治疗合并症以防止死亡。据我们所知，外周血中这些细胞未增多且无相关甲状腺功能减退证据的嗜碱性/嗜酸性心包积液的发生较为罕见。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8189/6637340/694e849c028d/CCR3-7-1280-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8189/6637340/694e849c028d/CCR3-7-1280-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8189/6637340/694e849c028d/CCR3-7-1280-g001.jpg

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本文引用的文献

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Transient Abnormal Myelopoiesis and AML in Down Syndrome: an Update.唐氏综合征中的短暂异常骨髓造血和急性髓系白血病：最新进展
Curr Hematol Malig Rep. 2016 Oct;11(5):333-41. doi: 10.1007/s11899-016-0338-x.
3
"Down syndrome: an insight of the disease".唐氏综合征：对该疾病的深入了解
J Biomed Sci. 2015 Jun 11;22(1):41. doi: 10.1186/s12929-015-0138-y.
4
Transient leukemia in down syndrome: report of two cases with review of literature.唐氏综合征中的短暂性白血病：两例报告并文献复习
Indian J Hematol Blood Transfus. 2011 Sep;27(3):172-6. doi: 10.1007/s12288-011-0079-x. Epub 2011 Jun 21.
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Transient myeloproliferative disorder and eosinophilic pericardial effusion in a down syndrome neonate.一名唐氏综合征新生儿的短暂性骨髓增殖性疾病和嗜酸性心包积液
Pediatr Hematol Oncol. 2008 Mar;25(2):123-9. doi: 10.1080/08880010801888220.
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Blood. 2004 Jan 15;103(2):399-406. doi: 10.1182/blood-2003-05-1556. Epub 2003 Sep 25.
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