Machiele Ryan, Renbarger Taylor, Guidry Bret
Campbell University School of Osteopathic Medicine in Lillington, North Carolina, USA.
Cape Fear Valley OBGYN Residency in Fayetteville, North Carolina, USA.
Case Rep Obstet Gynecol. 2019 May 27;2019:2174051. doi: 10.1155/2019/2174051. eCollection 2019.
Renal Cell Carcinoma (RCC) accounts for approximately 2-3% of all adult cancers and carries the highest mortality of the genitourinary cancers. Metastatic disease is seen in approximately 16% of cases and when present represents an advanced status. Metastasis of RCC to the vagina has rarely been cited in literature and when present can mimic primary vaginal cancer in clinical presentation and symptoms. Biopsy is performed to delineate the etiology and, in the presence of clear cells and certain immunohistochemistry markers, RCC needs to be included in the differential diagnosis. Treatment protocols are limited due to the rarity of the condition, with retrospective and comparative studies alongside cervical cancer treatment protocols serving as the basis. Herein, we describe a unique case of profuse vaginal bleeding secondary to vaginal metastases of RCC and discuss the relevant aspects of diagnosis and treatment.
肾细胞癌（RCC）约占所有成人癌症的2%-3%，是泌尿生殖系统癌症中死亡率最高的。约16%的病例会出现转移性疾病，一旦出现则表明病情已进展到晚期。RCC转移至阴道的情况在文献中鲜有报道，一旦发生，其临床表现和症状可酷似原发性阴道癌。需进行活检以明确病因，若存在透明细胞及某些免疫组化标志物，则在鉴别诊断中需考虑RCC。由于该病症罕见，治疗方案有限，目前的治疗方案以回顾性和对比性研究以及宫颈癌治疗方案为基础。在此，我们描述一例因RCC阴道转移导致大量阴道出血的独特病例，并讨论诊断和治疗的相关方面。
