用超小金纳米颗粒进行分子光声成像。
Molecular photoacoustic imaging with ultra-small gold nanoparticles.
作者信息
Han Sangheon, Bouchard Richard, Sokolov Konstantin V
机构信息
Department of Bioengineering, Rice University, 6100 Main Street, Houston, TX 77005, USA.
Department of Imaging Physics, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
出版信息
Biomed Opt Express. 2019 Jun 20;10(7):3472-3483. doi: 10.1364/BOE.10.003472. eCollection 2019 Jul 1.
Abstract
Gold nanoparticles (AuNPs) below 10 nm in size can undergo renal clearance, which could facilitate their clinical translation. However, due to non-linear, direct relationship between their absorption and size, use of such "ultra-small" AuNPs as contrast agents for photoacoustic imaging (PAI) is challenging. This problem is complicated by the tendency of absorption for ultra-small AuNPs to be below the NIR range, which is optimal for imaging. Herein, we present 5-nm molecularly activated plasmonic nanosensors (MAPS) that produce a strong photoacoustic signal in labeled cancer cells in the NIR, demonstrating the feasibility of sensitive PAI with ultra-small AuNPs.
摘要
尺寸小于10纳米的金纳米颗粒（AuNPs）可通过肾脏清除，这有助于它们的临床转化。然而，由于其吸收与尺寸之间存在非线性直接关系，将此类“超小”AuNPs用作光声成像（PAI）的造影剂具有挑战性。超小AuNPs的吸收倾向于低于对成像最理想的近红外范围，这使问题变得更加复杂。在此，我们展示了5纳米的分子激活等离子体纳米传感器（MAPS），其在近红外区域的标记癌细胞中产生强烈的光声信号，证明了使用超小AuNPs进行灵敏PAI的可行性。
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