Department of General Practice, Sir Run Run Shaw Hospital, Zhejiang University, China.
J Diabetes Res. 2019 Jul 7;2019:5904264. doi: 10.1155/2019/5904264. eCollection 2019.
This study adopts the method of retrospective analysis to collect general information and laboratory results of physical examination population, hoping to clarify the correlation between uric acid and thyroid hormone.
The subjects of the study were healthy subjects who underwent physical examination at the Sir Run Run Shaw Hospital affiliated to the Medical College of Zhejiang University from January 2016 to December 2018. Demographic information and medical history of all subjects were recorded through an electronic health system. Serum uric acid (SUA) was grouped by quartiles. Statistical analyses were performed with R version 3.5.1.
A total of 48,526 subjects were included in the analysis. Gender ratio, age, BMI, waist circumference, systolic blood pressure, diastolic blood pressure, FBG, HbA1c, TG, HDL-C, ALT, AST, FT3, FT4, and TSH were significantly different among the uric acid groups. The regression coefficients of SUA in the TSH, FT3, and FT4 regression models were = 1.000 (95% CI 1.000-1.000, = 0.009), = 0.999 (95% CI 0.999-0.999, < 0.001), and = 1.001 (95% CI 1.001-1.001, < 0.001), respectively. There was a significant dose-dependent relationship between FT4, FT3, and SUA gradient.
Under normal thyroid function, there were significant differences in TSH, FT3, and FT4 between groups with different uric acid levels. Uric acid levels were linearly correlated with FT3 and FT4, but not with TSH.
本研究采用回顾性分析的方法，收集体检人群的一般资料和实验室结果，旨在阐明尿酸与甲状腺激素之间的相关性。
研究对象为 2016 年 1 月至 2018 年 12 月在浙江大学医学院附属邵逸夫医院体检的健康人群。通过电子健康系统记录所有受试者的人口统计学信息和病史。根据血清尿酸（SUA）四分位值进行分组。采用 R 版本 3.5.1 进行统计分析。
共纳入 48526 例受试者。尿酸组间的性别比例、年龄、BMI、腰围、收缩压、舒张压、FBG、HbA1c、TG、HDL-C、ALT、AST、FT3、FT4 和 TSH 差异均有统计学意义。在 TSH、FT3 和 FT4 回归模型中，SUA 的回归系数分别为 = 1.000（95%CI 1.000-1.000， = 0.009）、 = 0.999（95%CI 0.999-0.999， < 0.001）和 = 1.001（95%CI 1.001-1.001， < 0.001）。FT4、FT3 和 SUA 梯度之间存在显著的剂量依赖性关系。
在甲状腺功能正常的情况下，不同尿酸水平组间 TSH、FT3 和 FT4 存在显著差异。尿酸水平与 FT3 和 FT4 呈线性相关，而与 TSH 无关。
