Abbasi Sarwat, Haleem Nadia, Jadoon Sara, Farooq Amjad
Department of Biochemistry, Ayub Medical College Abbottabad, Pakistan.
Department of Surgery, Ayub Medical College Abbottabad, Pakistan.
J Ayub Med Coll Abbottabad. 2019 Jan-Mar;31(1):64-66.
Non-alcoholic fatty liver disorder is a clinicopathological condition, characterized by macro vesicular steatosis in hepatic cells and metabolic stress related disorders without other causes of chronic hepatic disease. Uric acid is basically a heterocyclic compound of hydrogen, carbon, oxygen and nitrogen. Uric acid is the metabolic end product of purine metabolism. Hyperuricemia is considered to be related with the causes responsible for the production of metabolic syndrome. It may cause gout, impaired renal function, hypertension, hypertriglyceridemia, obesity and diabetes mellitus. The objective of study is to investigate the association of non-alcoholic fatty liver disease (NAFLD) and serum uric acid level.
This cross-sectional study was conducted at Ayub Teaching institute Abbottabad. According to predesigned questionnaire and informed consent, 100 subjects between ages 40-50 years were selected for the study. Data collected and analysis done by SPSS version 20.
It was observed that 20 (40%) subjects developed NAFLD as compared to 30(60%) of the subjects with normal serum uric acid level. Chi-square test was applied and values found to be significant (p=0.013).
Our study shows association of NAFLD with serum uric acid level.
非酒精性脂肪性肝病是一种临床病理状态，其特征为肝细胞大泡性脂肪变性以及与代谢应激相关的疾病，且无其他慢性肝病病因。尿酸基本上是由氢、碳、氧和氮组成的杂环化合物。尿酸是嘌呤代谢的终产物。高尿酸血症被认为与代谢综合征的病因有关。它可能导致痛风、肾功能损害、高血压、高甘油三酯血症、肥胖症和糖尿病。本研究的目的是调查非酒精性脂肪性肝病（NAFLD）与血清尿酸水平之间的关联。
本横断面研究在阿伯塔巴德阿尤布教学医院进行。根据预先设计的问卷并获得知情同意，选择了100名年龄在40至50岁之间的受试者进行研究。数据收集和分析使用SPSS 20版完成。
观察到20名（40%）受试者发生了非酒精性脂肪性肝病，而血清尿酸水平正常的受试者有30名（60%）。应用卡方检验，发现差异具有统计学意义（p = 0.013）。
我们的研究表明非酒精性脂肪性肝病与血清尿酸水平有关。
