Kırgezen Tolga, Server Ela Araz, Turanoğlu Fulya Savran, Yiğit Özgür, Uzun Hafize, Durmuş Sinem
Department of Otorhinolaryngology, İstanbul Training and Research Hospital, İstanbul, Turkey.
Department of Biochemistry, İstanbul University, Cerrahpaşa School of Medicine, İstanbul, Turkey.
Turk Arch Otorhinolaryngol. 2019 Jun;57(2):91-94. doi: 10.5152/tao.2019.4127. Epub 2019 Jun 1.
Eosinophil cationic protein (ECP) plays a significant role in the pathogenesis of atopic diseases such as allergic rhinitis (AR) and asthma. Using saliva as a diagnostic material is a non-invasive, simple method. Analysis of ECP in saliva was shown as an alternative diagnostic contribution in patients with asthma. In this study we aimed to assess a possible association between the levels of salivary ECP and the diagnosis of AR by comparing serum ECP and salivary ECP levels.
Thirty-five allergic rhinitis patients (study group) sensitive to Dermatophagoides farinae (D2) in skin prick test (SPT) and 35 nonallergic, SPT negative, healthy volunteers (control group) were included in the study. Salivary ECP, serum ECP and specific IgE D2 levels were measured.
Distribution of age and gender were similar in the study and the control groups (p>0.05). Serum specific IgE D2 levels were significantly higher in the study group compared to the control group (p<0.001). ECP levels in saliva and serum did not show any significant difference in between study and control groups (p=0.738; p=0.796, respectively). No significant difference was found between the levels of ECP in between the serum and the saliva of study and control groups. (p=0.504; p=0.589, respectively). There was no significant correlation between saliva and serum ECP levels of both groups.(r=-0.191/p=0.114).
Serum and saliva ECP levels seem close to each other and were comparable in both groups, but we did not find any correlation between them Although we hypothesized that saliva ECP may be used as a non-invasive method for the diagnosis of AR, it seems that this parameter is not helpful in diagnosis of AR.
嗜酸性粒细胞阳离子蛋白（ECP）在变应性疾病如变应性鼻炎（AR）和哮喘的发病机制中起重要作用。将唾液用作诊断材料是一种非侵入性的简单方法。唾液中ECP的分析被证明是哮喘患者的一种替代诊断方法。在本研究中，我们旨在通过比较血清ECP和唾液ECP水平来评估唾液ECP水平与AR诊断之间的可能关联。
本研究纳入了35名皮肤点刺试验（SPT）对粉尘螨（D2）敏感的变应性鼻炎患者（研究组）和35名非变应性、SPT阴性的健康志愿者（对照组）。测量唾液ECP、血清ECP和特异性IgE D2水平。
研究组和对照组的年龄和性别分布相似（p>0.05）。研究组的血清特异性IgE D2水平显著高于对照组（p<0.001）。研究组和对照组之间唾液和血清中的ECP水平无显著差异（分别为p=0.738；p=0.796）。研究组和对照组的血清与唾液中的ECP水平之间无显著差异（分别为p=0.504；p=0.589）。两组的唾液和血清ECP水平之间无显著相关性（r=-·0.191/p=0.114）。
血清和唾液中的ECP水平在两组中似乎相近且具有可比性，但我们未发现它们之间存在任何相关性。尽管我们假设唾液ECP可作为AR的一种非侵入性诊断方法，但该参数似乎对AR的诊断并无帮助。
