Department of Child and Social Dentistry, School of Dentistry, São Paulo State University (UNESP), Araçatuba, Brazil.
Department of Basic Sciences, School of Dentistry, São Paulo State University (UNESP), Araçatuba, Brazil.
J Periodontol. 2019 Dec;90(12):1423-1430. doi: 10.1002/JPER.19-0053. Epub 2019 Aug 18.
Anorexia and bulimia nervosa can have significant effects on oral health. Assessment of enzyme concentrations in saliva can be useful for obtaining information on molecular biomarkers for the prevention, monitoring, and diagnosis of oral diseases. This study investigated the periodontal condition, changes in salivary biochemical parameters, and oral health-related quality of life (OHRQoL) in patients with anorexia and bulimia nervosa.
The study comprised 60 women patients who attended a Brazilian medical school. Participants were divided into two groups: patients with anorexia and bulimia nervosa (ABN; n = 30) and control patients (CN; n = 30). Oral clinical examinations were carried out to evaluate the periodontal condition by Community Periodontal Index, and interviews using the Oral Health Impact Profile (OHIP-14) were conducted to assess OHRQoL. Saliva samples were collected for the evaluation of salivary concentrations of total protein, alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and thiobarbituric acid reactive substance (TBARS), and salivary flow rate.
Periodontal condition in the ABN group was significantly worse than that in the CN group. The ABN group showed significantly higher salivary concentrations of total protein, AST, ALT, and LDH than the CN group. There was no significant difference in the salivary concentrations of TBARS among the groups. The OHIP-14 score was higher in the ABN group than in the CN group.
Anorexia and bulimia nervosa are associated with poor periodontal condition, elevated salivary concentrations of total protein, AST, ALT, and LDH, decreased salivary flow rate and a significant adverse impact on OHRQoL.
神经性厌食症和神经性贪食症会对口腔健康产生重大影响。评估唾液中的酶浓度对于获得有关口腔疾病预防、监测和诊断的分子生物标志物的信息可能是有用的。本研究调查了神经性厌食症和神经性贪食症患者的牙周状况、唾液生化参数变化和口腔健康相关生活质量（OHRQoL）。
该研究纳入了 60 名到巴西医学院就诊的女性患者。参与者分为两组：神经性厌食症和神经性贪食症患者（ABN；n=30）和对照组患者（CN；n=30）。进行口腔临床检查，使用社区牙周指数评估牙周状况，并进行访谈，使用口腔健康影响量表（OHIP-14）评估 OHRQoL。收集唾液样本以评估总蛋白、丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）、乳酸脱氢酶（LDH）和硫代巴比妥酸反应物质（TBARS）的唾液浓度以及唾液流率。
ABN 组的牙周状况明显差于 CN 组。ABN 组的总蛋白、AST、ALT 和 LDH 唾液浓度明显高于 CN 组。三组间 TBARS 的唾液浓度无显著差异。ABN 组的 OHIP-14 评分高于 CN 组。
神经性厌食症和神经性贪食症与牙周状况不佳、总蛋白、AST、ALT 和 LDH 唾液浓度升高、唾液流率降低以及 OHRQoL 显著受损有关。
