9至18岁健康儿童人群在3T心脏磁共振成像上的天然T1和T2弛豫时间的正常值。
Normal values of native T and T relaxation times on 3T cardiac MR in a healthy pediatric population aged 9-18 years.
作者信息
Barczuk-Falęcka Marzena, Małek Łukasz A, Werys Konrad, Roik Danuta, Adamus Kalina, Brzewski Michał
机构信息
Department of Pediatric Radiology, Medical University of Warsaw, Poland.
Department of Epidemiology, Cardiovascular Disease Prevention and Health Promotion, Institute of Cardiology, Warsaw, Poland.
出版信息
J Magn Reson Imaging. 2020 Mar;51(3):912-918. doi: 10.1002/jmri.26886. Epub 2019 Jul 30.
BACKGROUND
Native myocardial T and T relaxation times are diagnostic tools used in clinical practice for adult and pediatric populations. Use of a mapping technique requires accurate knowledge of normal ranges in healthy patients, which is lacking in pediatric populations.
PURPOSE
To establish normal values for native T and T mapping in healthy pediatric subjects of different ages and sex.
STUDY TYPE
Prospective.
POPULATION
Thirty-eight healthy children (9-18 years; mean age 14.0 ± 2.7).
FIELD STRENGTH
Cardiac MR with a 3T scanner. T and T mapping using MyoMaps software.
ASSESSMENT
T and T relaxation times were calculated from a 0.7-1.0 cm region of interest placed at the mid-ventricular short-axis slice in the interventricular septum by two observers. Inter- and intraobserver variability was assessed.
STATISTICAL TESTS
The Student's t-test or the Mann-Whitney test for unpaired samples was applied to compare one continuous variable between two category groups. One-way analysis of variance (ANOVA) or a Kruskal-Wallis test was applied to compare one continuous variable between three category groups. Correlation between two continuous variables was assessed with a Pearson or Spearman test.
RESULTS
The mean native T relaxation time was 1223 ± 29 msec and T relaxation time was 43 ± 4.5 msec. There was no correlation between T /T values and age or body surface area (for T P = 0.94 and 0.90 and for T P = 0.19 and 0.64, respectively). There was weak correlation between T values and body mass index (BMI) (r = 0.448, P = 0.005). T values were significantly higher in females compared with males (44.6 ± 4.2 vs. 40.4 ± 3.8 msec, P = 0.002). We found a significant rise of T relaxation time in the pubertal period (age 13-15 years) comparing to prepubertal (age 9-12 years). Inter- and intraobserver agreement of T (r = 0.93; r = 0.99) and T (r = 0.96; r = 0.95) were high.
DATA CONCLUSION
We report normal values of native T and T relaxation times obtained with Myomaps software for 3T cardiac MR in a healthy pediatric population.
LEVEL OF EVIDENCE
2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;51:912-918.
背景
心肌固有T和T*弛豫时间是临床实践中用于成人和儿童群体的诊断工具。映射技术的应用需要准确了解健康患者的正常范围，而儿童群体缺乏这方面的数据。
目的
建立不同年龄和性别的健康儿童心肌固有T和T*映射的正常值。
研究类型
前瞻性研究。
研究对象
38名健康儿童（9 - 18岁；平均年龄14.0 ± 2.7岁）。
场强
使用3T扫描仪进行心脏磁共振成像。采用MyoMaps软件进行T和T*映射。
评估
由两名观察者在室间隔心室短轴切片上放置一个0.7 - 1.0 cm的感兴趣区域，计算T和T*弛豫时间。评估观察者间和观察者内的变异性。
统计检验
应用学生t检验或非配对样本的曼 - 惠特尼检验来比较两个类别组之间的一个连续变量。应用单因素方差分析（ANOVA）或克鲁斯卡尔 - 沃利斯检验来比较三个类别组之间的一个连续变量。用皮尔逊或斯皮尔曼检验评估两个连续变量之间的相关性。
结果
心肌固有T弛豫时间的平均值为1223 ± 29毫秒，T弛豫时间为43 ± 4.5毫秒。T/T值与年龄或体表面积之间无相关性（T的P值分别为0.94和0.90，T的P值分别为0.19和0.64）。T值与体重指数（BMI）之间存在弱相关性（r = 0.448，P = 0.005）。女性的T值显著高于男性（44.6 ± 4.2毫秒对40.4 ± 3.8毫秒，P = 0.002）。我们发现青春期（13 - 15岁）的T弛豫时间比青春期前（9 - 12岁）有显著升高。观察者间和观察者内T（r = 0.93；r = 0.99）和T（r = 0.96；r = 0.95）的一致性很高。
数据结论
我们报告了在健康儿童群体中使用Myomaps软件通过3T心脏磁共振成像获得的心肌固有T和T*弛豫时间的正常值。
证据水平
2 技术功效：2级 《磁共振成像杂志》2020年；51:912 - 918。
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