Pagano Joseph J, Yim Deane, Lam Christopher Z, Yoo Shi-Joon, Seed Mike, Grosse-Wortmann Lars
Department of Pediatrics, Division of Cardiology, Stollery Children's Hospital, University of Alberta, Edmonton, Canada (J.J.P.); Department of Paediatrics, Division of Cardiology (D.Y., S.J.Y., M.S., L.G.W.) and Department of Diagnostic Imaging (C.Z.L., S.J.Y., M.S., L.G.W.), The Hospital for Sick Children, University of Toronto, Toronto, Canada; and Department of Cardiology, Princess Margaret Hospital for Children, Perth, Australia (D.Y.).
Radiol Cardiothorac Imaging. 2020 Aug 13;2(4):e190234. doi: 10.1148/ryct.2020190234. eCollection 2020 Aug.
To establish normative data for myocardial T1, including extracellular volume (ECV) fraction, in healthy children.
In this retrospective, single-center study, T1 mapping data were collected from 48 healthy pediatric patients (14 years ± 3 [standard deviation]; range, 9-18 years; 27 of 48 [56%] male) referred for cardiac screening 1.5-T MRI between 2014 and 2017. T1 relaxometry was performed using a 5(number of heartbeats [nHB])3 modified Look-Locker inversion recovery (MOLLI) sequence, where nHB was three to five heartbeats depending on the heart rate, and was repeated 15 minutes following the administration of 0.2 mmol per kilogram of body weight of gadobenate dimeglumine, with 19 patients receiving contrast material. T1 values were calculated using a curve-fitting algorithm on average region-of-interest signal and corrected for imperfect inversion pulse efficiency. Comparisons within patients were performed with paired Student test, between groups with unpaired Student test or Mann-Whitney test, and linear regression was performed to examine for associations with other variables.
Average native T1 was 1008 msec ± 31, with a nonsignificant increase in females (1017 msec ± 27 vs 1001 msec ± 33, = .066). Average ECV was 20.8% ± 2.4, with a nonsignificant increase in values in females (21.7% ± 1.9 vs 20.0% ± 2.6, = .123). T1 and ECV values were increased in the septum versus the free wall.
Normative data are presented for myocardial native T1 and ECV using the MOLLI T1 mapping sequence at 1.5 T.© RSNA, 2020.
建立健康儿童心肌T1的规范数据，包括细胞外容积（ECV）分数。
在这项回顾性单中心研究中，收集了2014年至2017年间因心脏筛查接受1.5-T磁共振成像（MRI）检查的48例健康儿科患者（14岁±3[标准差]；范围9-18岁；48例中的27例[56%]为男性）的T1映射数据。使用5（心跳数[nHB]）3改良Look-Locker反转恢复（MOLLI）序列进行T1弛豫测量，其中nHB根据心率为3至5次心跳，并在静脉注射每千克体重0.2 mmol钆贝葡胺15分钟后重复测量，19例患者接受了对比剂。使用曲线拟合算法根据平均感兴趣区信号计算T1值，并针对不完全反转脉冲效率进行校正。患者内比较采用配对t检验，组间比较采用非配对t检验或Mann-Whitney检验，并进行线性回归以检查与其他变量的相关性。
平均固有T1为1008毫秒±31，女性有非显著性增加（1017毫秒±27对1001毫秒±33，P = 0.066）。平均ECV为20.8%±2.4，女性值有非显著性增加（21.7%±1.9对20.0%±2.6，P = 0.123）。与游离壁相比，间隔的T1和ECV值增加。
给出了使用1.5 T的MOLLI T1映射序列获得的心肌固有T1和ECV的规范数据。© RSNA，2020年。
