生活方式体力活动对无症状周围动脉疾病血管功能的影响。

Effects of Lifestyle Physical Activity on Vascular Function in Asymptomatic Peripheral Arterial Disease.

机构信息

University of St. Augustine for Health Sciences, San Marcos, CA.

Point Loma Nazarene University, Point Loma, CA.

出版信息

Med Sci Sports Exerc. 2020 Jan;52(1):8-15. doi: 10.1249/MSS.0000000000002109.

DOI:10.1249/MSS.0000000000002109

PMID:31361714

Abstract

PURPOSE

The purpose of this study was to examine the effects of a 12-wk in-home self-monitored physical activity (PA) program targeting a combination of lifestyle PA program on changes in endothelial reactivity, arterial stiffness, sedentary behaviors, and upright and stepping activities in individuals with asymptomatic peripheral arterial disease (APAD).

METHODS

Participants (n = 38) with APAD (ages 52-87 yr) were randomized to attention control (AC) or a PA sedentary reduction (PASR) group using an interactive online 3-month program focusing on increasing lifestyle PA and decreasing sedentary behaviors. The ActivPal™ PA monitor was used to measure postural and stepping parameters. Endothelial reactivity (peripheral arterial tone-reactive hyperemia index [PAT-RHI]) and augmentation index (AIx) were measured using the EndoPAT™ system at baseline and 3 months.

RESULTS

The PASR group significantly decreased daily sit/lie hours (-0.80 ± 0.87 vs 0.18 ± 0.77 P = 0.001), increased sit-to-stand transitions per day (7.1 ± 10.5 vs -1.4 ± 5.71, P < 0.001), and increased daily step counts (2814 ± 1753 vs 742 ± 1321, P < 0.001). The PASR group also increased steps per day accumulated within specific cadence bands 61-80 steps per minute (1252 ± 447 vs 177 ± 359, P < 0.001), 81-100 steps per minute band (919 ± 511 vs -98 ± 697, P < 0.001), and within the 101-120 steps per minute band (415 ± 625 vs -327 ± 467, P < 0.001) versus the AC group. PAT-RHI significantly increased in the PASR group (0.179 ± 0.180 vs 0.0.044 ± 0.101, P = 0.019), whereas no significant changes were observed in PAT-AIx.

CONCLUSIONS

Modest improvements in microvascular reactivity, PA, sedentary behavior, but not arterial stiffness were demonstrated after a 12-wk intervention targeting sedentary behavior reduction and increased lifestyle PA in individuals with APAD.

摘要

目的

本研究旨在探讨为期 12 周的家庭自我监测体力活动（PA）方案对无症状外周动脉疾病（APAD）患者内皮反应性、动脉僵硬度、久坐行为以及直立和跨步活动变化的影响。

方法

将 38 名（年龄 52-87 岁）APAD 患者随机分为对照组（AC）或 PA 减少久坐组（PASR），采用在线互动式 3 个月方案，重点增加生活方式 PA 和减少久坐行为。使用 ActivPal™ PA 监测器测量姿势和跨步参数。使用 EndoPAT™系统在基线和 3 个月时测量内皮反应性（外周动脉张力反应性充血指数[PAT-RHI]）和增强指数（AIx）。

结果

PASR 组每天的久坐/躺卧时间显著减少（-0.80±0.87 比 0.18±0.77，P=0.001），每天的坐立转换次数增加（7.1±10.5 比-1.4±5.71，P<0.001），每日步数增加（2814±1753 比 742±1321，P<0.001）。PASR 组还增加了特定步频范围内的每日步数：61-80 步/分钟（1252±447 比 177±359，P<0.001）、81-100 步/分钟（919±511 比-98±697，P<0.001）和 101-120 步/分钟（415±625 比-327±467，P<0.001）。PASR 组 PAT-RHI 显著增加（0.179±0.180 比 0.0.044±0.101，P=0.019），而 PAT-AIx 无显著变化。