Hematology/Oncology Pharmacy Services, University of North Carolina Healthcare, and UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC.
UF Health Personalized Medicine Program, University of Florida, and Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL.
Am J Health Syst Pharm. 2019 Apr 8;76(8):521-529. doi: 10.1093/ajhp/zxz024.
This report examines and evaluates pharmacogenomics as an emerging science as it relates to the Practice Advancement Initiative and its predecessor the Pharmacy Practice Model Initiative's consensus statements for optimal pharmacy practice models.
Pharmacogenomics is one of many emerging sciences to impact medication management and delivery of patient care. Increasingly, biomarkers are included in drug labeling and can assist pharmacists with personalizing medicine to optimize patient therapies and avoid adverse effects. The 2011 ASHP Pharmacy Practice Model Summit generated a list of 147 consensus statements for optimal pharmacy practice. Of these, 1 statement explicitly describes adjustment of drug regimens based on genetic factors as an essential activity of pharmacist-provided drug regimens, and 9 other statements provide additional support for incorporation of this emerging science into all aspects of patient care provided by pharmacists. We describe 4 institutions that have made significant inroads to implementing pharmacogenomics, to provide a framework and serve as resources for other institutions initiating their own pharmacogenomics implementation journeys.
Through prioritized efforts of the pharmacy profession and health care institutions, pharmacogenomics will be disseminated and implemented, and the goal of the Pharmacy Practice Model Initiative's consensus statements of improving health care using patients' genetic characteristics will be realized.
本报告审视和评估了作为一门新兴科学的药物基因组学，因为它与实践推进倡议及其前身药房实践模式倡议的共识声明有关，这些共识声明旨在为最佳药房实践模式提供指导。
药物基因组学是影响药物管理和患者护理的众多新兴科学之一。越来越多的生物标志物被纳入药物标签，这可以帮助药剂师个性化用药，以优化患者治疗效果并避免不良反应。2011 年 ASHP 药房实践模式峰会生成了一份包含 147 项最佳药房实践共识声明的清单。其中，有 1 项声明明确将根据遗传因素调整药物方案描述为药剂师提供药物方案的基本活动，还有 9 项其他声明为将这一新兴科学纳入药剂师提供的所有患者护理方面提供了额外支持。我们描述了 4 家在实施药物基因组学方面取得重大进展的机构，为其他机构提供了一个框架，并作为他们开始自己的药物基因组学实施之旅的资源。
通过药剂师行业和医疗机构的优先努力，药物基因组学将得到传播和实施，药房实践模式倡议的共识声明中利用患者遗传特征改善医疗保健的目标也将得以实现。
