HIV 感染孕妇的妊娠期糖尿病：系统评价和荟萃分析。
Gestational diabetes mellitus in HIV-infected pregnant women: A systematic review and meta-analysis.
机构信息
Department of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Department of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
出版信息
Diabetes Res Clin Pract. 2019 Sep;155:107800. doi: 10.1016/j.diabres.2019.107800. Epub 2019 Jul 27.
BACKGROUND
Impaired glucose metabolism during pregnancy can result in a significant adverse pregnancy-outcomes. Previous studies have reported the contribution of ART to the impaired glucose tolerance and gestational diabetes mellitus (GDM) in HIV-infected pregnant women.
METHODS
PRISMA guideline was followed for this systematic review and meta-analysis. The STATA version 11 was employed to compute the pooled prevalence of GDM using the random effect model and 95% confidence interval. Subgroup analysis was conducted by geographical regions. Visual inspection of the funnel plot and Egger's regression test statistic were used to show the publication bias.
RESULTS
A total of 13,517 articles were identified, of which 21 publications met the inclusion criteria. The pooled prevalence of GDM among HIV-infected pregnant women was 4.42% (95% CI: 3.48; 5.35). According to the subgroup analysis, the pooled prevalence of GDM among HIV-infected pregnant women was 7.1% (95%CI: 3.38; 10.76) in Asia, 5.83% (95% CI: 2.61; 9.04) in Europe, 3.58% (95% CI: 2.67; 4.50) in America and 3.19% (95% CI: -2.89; 9.27) in Africa.
CONCLUSION
The pooled prevalence of GDM among HIV-infected pregnant women is expectedly high. Therefore, early screening of HIV-infected pregnant women for GDM is vital to reduce its complications related to pregnancy.
PROTOCOL REGISTRATION NUMBER
International Prospective Register of Systematic Reviews CRD42018090735.
背景
妊娠期间葡萄糖代谢受损可导致妊娠结局显著不良。既往研究报道辅助生殖技术（ART）可导致 HIV 感染孕妇葡萄糖耐量受损和妊娠期糖尿病（GDM）。
方法
本系统评价和荟萃分析遵循 PRISMA 指南。采用 STATA 版本 11 采用随机效应模型和 95%置信区间计算 GDM 的汇总患病率。通过地理区域进行亚组分析。使用漏斗图和 Egger 回归检验统计量进行发表偏倚的可视化检查。
结果
共确定了 13517 篇文章，其中 21 篇符合纳入标准。HIV 感染孕妇中 GDM 的汇总患病率为 4.42%（95%CI：3.48；5.35）。根据亚组分析，HIV 感染孕妇中 GDM 的汇总患病率在亚洲为 7.1%（95%CI：3.38；10.76），欧洲为 5.83%（95%CI：2.61；9.04），美洲为 3.58%（95%CI：2.67；4.50），非洲为 3.19%（95%CI：-2.89；9.27）。
结论
HIV 感染孕妇中 GDM 的汇总患病率预计较高。因此，早期筛查 HIV 感染孕妇的 GDM 对于降低与妊娠相关的并发症至关重要。
注册编号
国际前瞻性系统评价注册库 CRD42018090735。
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