糖尿病视网膜病变的病理生理学：实验室研究的贡献和局限性。
Pathophysiology of Diabetic Retinopathy: Contribution and Limitations of Laboratory Research.
机构信息
Gavin Herbert Eye Institute, University of California Irvine, Irvine, California, USA,
Veterans Administration Medical Center Research Service 151, Cleveland, Ohio, USA,
出版信息
Ophthalmic Res. 2019;62(4):196-202. doi: 10.1159/000500026. Epub 2019 Jul 30.
Abstract
Preclinical models of diabetic retinopathy are indispensable in the drug discovery and development of new therapies. They are, however, imperfect facsimiles of diabetic retinopathy in humans. This chapter discusses the advantages, limitations, and physiological and pathological relevance of preclinical models of diabetic retinopathy. The judicious interpretation and extrapolation of data derived from these models to humans and a correspondingly greater emphasis placed on translational medical research in early-stage clinical trials are essential to more successfully inhibit the development and progression of diabetic retinopathy in the future.
摘要
糖尿病性视网膜病变的临床前模型在新药发现和治疗开发中不可或缺。然而，这些模型并不能完美地模拟人类的糖尿病性视网膜病变。本章讨论了糖尿病性视网膜病变的临床前模型的优点、局限性以及其与生理和病理的相关性。明智地解释和推断这些模型得出的数据，并在早期临床试验中更加重视转化医学研究，对于未来更成功地抑制糖尿病性视网膜病变的发展和进展至关重要。
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