State Key Laboratory of Biochemical Engineering, Institute of Process Engineering , Chinese Academy of Sciences , Beijing 100190 , PR China.
School of Chemical Engineering , University of Chinese Academy of Sciences , Beijing 100049 , PR China.
ACS Appl Mater Interfaces. 2019 Aug 28;11(34):30542-30550. doi: 10.1021/acsami.9b08011. Epub 2019 Aug 13.
Biodegradation is a mild and efficient way to protect humans and animals from mycotoxins. However, microbes and enzymes are susceptible to environmental change, lack of stability, and reusability. In this work, three peroxidase-like metal-organic frameworks (MOFs), as artificial substitutes of natural peroxidase, are used for aflatoxin B (AFB) removal, demonstrating the strong removal ability for AFB and anti-interference ability toward other substances. There are distinct adsorption and catalytic properties among these MOFs that are mainly because of the differences in structure and Fe ion active sites. Then, we immobilized these MOFs into ultrafiltration membranes to form a multifunctional membrane (i.e., filtration, adsorption, and catalysis) for AFB removal with good reusability that can be operated in simultaneous adsorption/catalysis or adsorption followed by catalysis/regeneration modes. Physicochemical analysis and animal experiments showed that the degradation products are probably several low-carbon substances whose toxic groups are cleaved.
生物降解是一种温和且高效的方法，可以保护人类和动物免受真菌毒素的侵害。然而，微生物和酶易受环境变化、缺乏稳定性和可重复使用性的影响。在这项工作中，三种过氧化物酶类似的金属有机骨架（MOFs）被用作天然过氧化物酶的人工替代品，用于去除黄曲霉毒素 B（AFB），表现出对 AFB 的强去除能力和对其他物质的抗干扰能力。这些 MOFs 之间存在明显的吸附和催化特性，这主要是由于结构和 Fe 离子活性位点的差异。然后，我们将这些 MOFs 固定到超滤膜中，形成一种多功能膜（即过滤、吸附和催化），用于去除 AFB，具有良好的可重复使用性，可以在同时吸附/催化或吸附后催化/再生模式下操作。物理化学分析和动物实验表明，降解产物可能是几种低碳物质，其毒性基团被切断。
