Health Service Vocational College, Canakkale 18 Mart University, Canakkale, Turkey.
Faculty of Medicine, Department of Obstetrics and Gynecology, Canakkale 18 Mart University, Canakkale, Turkey.
Gynecol Endocrinol. 2020 Nov;36(11):1006-1009. doi: 10.1080/09513590.2020.1769062. Epub 2020 May 21.
This study aimed to study the dynamic thiol/disulfide homeostasis in pregnant women with gestational diabetes mellitus (GDM). Forty-five pregnant women with GDM and 45 age-matched healthy pregnancies were included in this study. Thiol/disulfide homeostasis was measured using a commercial kit (Rel Assay Diagnostics). The patients with GDM had significantly higher disulfide concentrations than healthy pregnant patients ( = .001). Besides, the GDM group had significantly higher disulfide/total thiol, disüplhide/native thiol, and native thiol/total thiol ratio than healthy pregnant patients ( = .001, = .001 and = .001, respectively). The significantly higher concentrations of disulfide, disulfide/total thiol, disüplhide/native thiol, and native thiol/total thiol ratio in women with GDM could be considered as the increased oxidative stress.
本研究旨在研究妊娠期糖尿病（GDM）孕妇的巯基/二硫键动态平衡。本研究纳入了 45 例 GDM 孕妇和 45 例年龄匹配的健康妊娠孕妇。使用商业试剂盒（Rel Assay Diagnostics）测量巯基/二硫键的动态平衡。GDM 患者的二硫键浓度明显高于健康孕妇（= 0.001）。此外，GDM 组的二硫键/总巯基、二硫键/天然巯基和天然巯基/总巯基比值明显高于健康孕妇（= 0.001、= 0.001 和 = 0.001）。GDM 妇女中二硫键、二硫键/总巯基、二硫键/天然巯基和天然巯基/总巯基比值浓度的显著升高可被认为是氧化应激的增加。
