Department of Endocrinology and Metabolism, Zhongshan Hospital Xiamen University, 201-209 Hubin South Road, Xiamen, 361004, China.
Department of Endocrinology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, 350001, China.
BMC Endocr Disord. 2019 Jul 30;19(1):83. doi: 10.1186/s12902-019-0414-z.
Thyroid dysfunction is one of the prevalent endocrine disorders. The relationship between lifestyle factors and thyroid dysfunction was not clear and some of the factors seemed paradoxical.
We conducted this population-based study using data from 5154 She ethnic minority people who had entered into the epidemic survey of diabetes between July 2007 to September 2009. Life style information was collected using a standard questionnaire. Body mass index (BMI), Blood pressure and serum TSH, TPOAb, triglycerides (TG), total cholesterol (TC) and high-density lipoprotein cholesterol (HDL) were collected.
The study showed that people who drank, had higher education or suffered from insomnia have lower incidence of hyperthyroidism. On the other hand, smoking, alcohol consumption, exercise, undergoing weight watch and chronic headache were associated with decreased incidence of hypothyroidism. Using multivariable logistic regression analysis, we found that alcohol consumption was associated with decreased probability of hyperthyroidism, hypothyroidism, as well as positive TPOAb. The amounts of cigarettes smoked daily displayed a positive correlation with hyperthyroidism among smokers. Accordingly, smoking seemed to be associated with decreased risk for hypothyroidism and positive TPOAb. Exercise and maintaining a healthy weight might have a beneficial effect on thyroid health. Interestingly, daily staple amount showed an inverse correlation with incidence of positive TPOAb.
Within the Chinese She ethnic minority, we found associations between different lifestyle factors and the incidence of different thyroid diseases. Understanding the nature of these associations requires further investigations.
甲状腺功能障碍是常见的内分泌疾病之一。生活方式因素与甲状腺功能障碍之间的关系尚不清楚，其中一些因素似乎相互矛盾。
我们使用 2007 年 7 月至 2009 年 9 月期间参加糖尿病流行情况调查的 5154 名畲族人群的数据进行了这项基于人群的研究。使用标准问卷收集生活方式信息。采集体重指数（BMI）、血压和血清促甲状腺激素（TSH）、甲状腺过氧化物酶抗体（TPOAb）、甘油三酯（TG）、总胆固醇（TC）和高密度脂蛋白胆固醇（HDL）。
研究表明，饮酒、受教育程度较高或患有失眠症的人患甲亢的发病率较低。另一方面，吸烟、饮酒、运动、体重监测和慢性头痛与甲减的发病率降低有关。通过多变量逻辑回归分析，我们发现饮酒与甲亢、甲减以及 TPOAb 阳性的可能性降低有关。吸烟者每天吸烟的数量与甲亢呈正相关。因此，吸烟似乎与甲减和 TPOAb 阳性的风险降低有关。运动和保持健康的体重可能对甲状腺健康有有益的影响。有趣的是，每天的主食摄入量与 TPOAb 阳性的发生率呈反比。
在畲族人群中，我们发现不同的生活方式因素与不同的甲状腺疾病的发病率之间存在关联。要了解这些关联的性质，需要进一步的研究。
