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A novel oncolytic virus engineered with PD-L1 scFv effectively inhibits tumor growth in a mouse model.

作者信息

Wu Chuanjian, Wu Manman, Liang Minglong, Xiong Sidong, Dong Chunsheng

机构信息

Jiangsu Key Laboratory of Infection and Immunity, The Institutes of Biology and Medical Sciences, Soochow University, 199 Ren-Ai Road, Suzhou, 215123, Jiangsu, China.

出版信息

Cell Mol Immunol. 2019 Sep;16(9):780-782. doi: 10.1038/s41423-019-0264-7. Epub 2019 Jul 30.

DOI:10.1038/s41423-019-0264-7
PMID:31363172
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6804750/
Abstract
摘要

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本文引用的文献

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PD-L1 upregulation in myeloma cells by panobinostat in combination with interferon-γ.帕比司他联合γ干扰素使骨髓瘤细胞中PD-L1上调。
Oncotarget. 2019 Mar 8;10(20):1903-1917. doi: 10.18632/oncotarget.26726.
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The altered PD-1/PD-L1 pathway delivers the 'one-two punch' effects to promote the Treg/Th17 imbalance in pre-eclampsia.PD-1/PD-L1 通路的改变会产生“双重打击”效应，促进子痫前期中 Treg/Th17 的失衡。
Cell Mol Immunol. 2018 Jul;15(7):710-723. doi: 10.1038/cmi.2017.70. Epub 2017 Sep 11.
3
Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy.溶瘤病毒疗法可促进肿瘤内T细胞浸润并改善抗PD-1免疫疗法。
Cell. 2017 Sep 7;170(6):1109-1119.e10. doi: 10.1016/j.cell.2017.08.027.
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Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy.抗程序性死亡配体1（PD-L1）单克隆抗体阿维鲁单抗用于肿瘤治疗的结构基础
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Selection and characterization of the novel anti-human PD-1 FV78 antibody from a targeted epitope mammalian cell-displayed antibody library.从靶向表位的哺乳动物细胞展示抗体文库中筛选和鉴定新型抗人 PD-1 FV78 抗体。
Cell Mol Immunol. 2018 Feb;15(2):146-157. doi: 10.1038/cmi.2016.38. Epub 2016 Aug 8.
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Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia.嵌合抗原受体T细胞在复发难治性慢性淋巴细胞白血病中持续存在并诱导持续缓解。
Sci Transl Med. 2015 Sep 2;7(303):303ra139. doi: 10.1126/scitranslmed.aac5415.
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Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future.人类癌症的抗PD-1/PD-L1疗法：过去、现在与未来。
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Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma.替莫唑胺胶丸联合放疗治疗恶性脑胶质瘤的疗效观察
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Signaling pathways in murine dendritic cells that regulate the response to vesicular stomatitis virus vectors that express flagellin.调节对表达鞭毛蛋白的水疱性口炎病毒载体的反应的小鼠树突状细胞中的信号通路。
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Programmed contraction of CD8(+) T cells after infection.感染后CD8(+) T细胞的程序性收缩
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